Seroatlas · Human Serome Atlas

ACTMAP

Actin maturation protease

Also known as: ACTMP_HUMAN, C19orf54, FLJ41131

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5BKX5
Gene: ACTMAP
Ensembl: ENSG00000188493
Chromosome: 19
Canonical length: 351 aa
Protein class: Predicted intracellular proteins
Subcellular location: Intermediate filaments,Centriolar satellite

OverviewNCBI Gene

Enables cysteine-type aminopeptidase activity and initiator methionyl aminopeptidase activity. Involved in protein processing. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>Q5BKX5|ACTMAP
     1  MTSPCSPPLK PPISPPKTPV PQASSIPSPP LPPSPLDFSA LPSPPWSQQT PVPPPLPLPP
    61  PPAATGPAPR HVFGLEKSQL LKEAFDKAGP VPKGREDVKR LLKLHKDRFR GDLRWILFCA
   121  DLPSLIQEGP QCGLVALWMA GTLLSPPSGV PLERLIRVAT ERGYTAQGEM FSVADMGRLA
   181  QEVLGCQAKL LSGGLGGPNR DLVLQHLVTG HPLLIPYDED FNHEPCQRKG HKAHWAVSAG
   241  VLLGVRAVPS LGYTEDPELP GLFHPVLGTP CQPPSLPEEG SPGAVYLLSK QGKSWHYQLW
   301  DYDQVRESNL QLTDFSPSRA TDGRVYVVPV GGVRAGLCGQ ALLLTPQDCS H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACTMAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

liver: 15 nTPM
skeletal muscle: 14 nTPM
small intestine: 10 nTPM
duodenum: 9.9 nTPM
tongue: 9.6 nTPM
adrenal gland: 9.5 nTPM

Single-cell type

epicardial cells: 114 nCPM
cardiomyocytes: 80 nCPM
adipocytes: 33 nCPM
early primary spermatocytes: 27 nCPM
epididymal basal cells: 25 nCPM
medullary thymic epithelial cells: 24 nCPM

Immune cell

myeloid DC: 5.7 nTPM
non-classical monocyte: 5.1 nTPM
classical monocyte: 4.5 nTPM
intermediate monocyte: 3.7 nTPM
plasmacytoid DC: 3.5 nTPM
T-reg: 1.9 nTPM

Brain region

medulla oblongata: 13 nTPM
white matter: 13 nTPM
pons: 12 nTPM
basal ganglia: 11 nTPM
cerebellum: 11 nTPM
midbrain: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein processing

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Actin maturation protease
Actin maturation protease-like, C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACTMAP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACTMAP as an antibody target. Whether an autoantibody or antibody against ACTMAP could matter depends on whether native ACTMAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACTMAP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACTMAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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