Seroatlas · Human Serome Atlas

PDLIM4

PDZ and LIM domain protein 4

Also known as: PDLI4_HUMAN, RIL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P50479
Gene
PDLIM4
Ensembl
ENSG00000131435
Chromosome
5
Canonical length
330 aa
Protein class
Human disease related genes, Predicted intracellular proteins
Subcellular location
Plasma membrane,Actin filaments,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables alpha-actinin binding activity; protein homodimerization activity; and protein phosphatase binding activity. Involved in actin cytoskeleton organization. Located in several cellular components, including lamellipodium; perinuclear region of cytoplasm; and stress fiber. Part of filamentous actin. Implicated in osteoporosis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>P50479|PDLIM4
     1  MPHSVTLRGP SPWGFRLVGG RDFSAPLTIS RVHAGSKAAL AALCPGDLIQ AINGESTELM
    61  THLEAQNRIK GCHDHLTLSV SRPEGRSWPS APDDSKAQAH RIHIDPEIQD GSPTTSRRPS
   121  GTGTGPEDGR PSLGSPYGQP PRFPVPHNGS SEATLPAQMS TLHVSPPPSA DPARGLPRSR
   181  DCRVDLGSEV YRMLREPAEP VAAEPKQSGS FRYLQGMLEA GEGGDWPGPG GPRNLKPTAS
   241  KLGAPLSGLQ GLPECTRCGH GIVGTIVKAR DKLYHPECFM CSDCGLNLKQ RGYFFLDERL
   301  YCESHAKARV KPPEGYDVVA VYPNAKVELV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDLIM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
99 nTPM

Expression across tissuesHPA

Tissue

  • colon: 99 nTPM
  • endometrium: 84 nTPM
  • choroid plexus: 73 nTPM
  • skin: 61 nTPM
  • blood vessel: 60 nTPM
  • heart muscle: 59 nTPM

Single-cell type

  • breast myoepithelial cells: 429 nCPM
  • decidual stromal cells: 265 nCPM
  • smooth muscle cells: 215 nCPM
  • esophageal apical cells: 199 nCPM
  • schwann cells: 191 nCPM
  • submucosal glandular cells: 185 nCPM

Immune cell

  • NK-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • medulla oblongata: 46 nTPM
  • hypothalamus: 39 nTPM
  • spinal cord: 36 nTPM
  • white matter: 33 nTPM
  • midbrain: 32 nTPM
  • choroid plexus: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
0.98
gnomAD missense Z
0.71
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDLIM4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDLIM4 as an antibody target. Whether an autoantibody or antibody against PDLIM4 could matter depends on whether native PDLIM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDLIM4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDLIM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDLIM4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...