Seroatlas · Human Serome Atlas

PDLIM1

PDZ and LIM domain protein 1

Also known as: CLIM1, CLP-36, CLP36, hCLIM1, PDLI1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00151
Gene
PDLIM1
Ensembl
ENSG00000107438
Chromosome
10
Canonical length
329 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cell Junctions,Actin filaments

OverviewNCBI Gene

This gene encodes a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. The protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14 and 17. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>O00151|PDLIM1
     1  MTTQQIDLQG PGPWGFRLVG GKDFEQPLAI SRVTPGSKAA LANLCIGDVI TAIDGENTSN
    61  MTHLEAQNRI KGCTDNLTLT VARSEHKVWS PLVTEEGKRH PYKMNLASEP QEVLHIGSAH
   121  NRSAMPFTAS PASSTTARVI TNQYNNPAGL YSSENISNFN NALESKTAAS GVEANSRPLD
   181  HAQPPSSLVI DKESEVYKML QEKQELNEPP KQSTSFLVLQ EILESEEKGD PNKPSGFRSV
   241  KAPVTKVAAS IGNAQKLPMC DKCGTGIVGV FVKLRDRHRH PECYVCTDCG TNLKQKGHFF
   301  VEDQIYCEKH ARERVTPPEG YEVVTVFPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDLIM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
653 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 653 nTPM
  • heart muscle: 378 nTPM
  • lung: 325 nTPM
  • adipose tissue: 292 nTPM
  • blood vessel: 282 nTPM
  • tongue: 271 nTPM

Single-cell type

  • megakaryocytes: 2,083 nCPM
  • platelets: 1,473 nCPM
  • decidual stromal cells: 1,112 nCPM
  • enterocytes: 1,048 nCPM
  • epididymal basal cells: 675 nCPM
  • migrating cytotrophoblasts: 671 nCPM

Immune cell

  • memory B-cell: 225 nTPM
  • naive B-cell: 214 nTPM
  • eosinophil: 190 nTPM
  • total PBMC: 44 nTPM
  • myeloid DC: 31 nTPM
  • memory CD8 T-cell: 14 nTPM

Brain region

  • choroid plexus: 44 nTPM
  • medulla oblongata: 27 nTPM
  • spinal cord: 13 nTPM
  • pons: 13 nTPM
  • thalamus: 13 nTPM
  • cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
gnomAD missense Z
0.76
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDLIM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDLIM1 as an antibody target. Whether an autoantibody or antibody against PDLIM1 could matter depends on whether native PDLIM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDLIM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDLIM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDLIM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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