Seroatlas · Human Serome Atlas

PDIA6

Protein disulfide-isomerase A6

Also known as: ERp5, P5, PDIA6_HUMAN, TXNDC7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15084
Gene
PDIA6
Ensembl
ENSG00000143870
Chromosome
2
Canonical length
440 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum,Primary cilium,Centriolar satellite,Basal body
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

440 residues, UniProt reviewed canonical sequence.

>Q15084|PDIA6
     1  MALLVLGLVS CTFFLAVNGL YSSSDDVIEL TPSNFNREVI QSDSLWLVEF YAPWCGHCQR
    61  LTPEWKKAAT ALKDVVKVGA VDADKHHSLG GQYGVQGFPT IKIFGSNKNR PEDYQGGRTG
   121  EAIVDAALSA LRQLVKDRLG GRSGGYSSGK QGRSDSSSKK DVIELTDDSF DKNVLDSEDV
   181  WMVEFYAPWC GHCKNLEPEW AAAASEVKEQ TKGKVKLAAV DATVNQVLAS RYGIRGFPTI
   241  KIFQKGESPV DYDGGRTRSD IVSRALDLFS DNAPPPELLE IINEDIAKRT CEEHQLCVVA
   301  VLPHILDTGA AGRNSYLEVL LKLADKYKKK MWGWLWTEAG AQSELETALG IGGFGYPAMA
   361  AINARKMKFA LLKGSFSEQG INEFLRELSF GRGSTAPVGG GAFPTIVERE PWDGRDGELP
   421  VEDDIDLSDV ELDDLGKDEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDIA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
395 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 395 nTPM
  • thyroid gland: 340 nTPM
  • liver: 244 nTPM
  • pancreas: 238 nTPM
  • salivary gland: 173 nTPM
  • cervix: 168 nTPM

Single-cell type

  • extravillous trophoblasts: 1,635 nCPM
  • epididymal principal cells: 1,039 nCPM
  • plasma cells: 859 nCPM
  • decidual stromal cells: 734 nCPM
  • migrating cytotrophoblasts: 727 nCPM
  • syncytiotrophoblasts: 664 nCPM

Immune cell

  • total PBMC: 319 nTPM
  • basophil: 277 nTPM
  • plasmacytoid DC: 269 nTPM
  • NK-cell: 242 nTPM
  • MAIT T-cell: 219 nTPM
  • myeloid DC: 215 nTPM

Brain region

  • choroid plexus: 83 nTPM
  • white matter: 71 nTPM
  • basal ganglia: 68 nTPM
  • thalamus: 67 nTPM
  • medulla oblongata: 63 nTPM
  • hypothalamus: 62 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PDIA6.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 88 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.25
gnomAD missense Z
0.7
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDIA6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDIA6 as an antibody target. Whether an autoantibody or antibody against PDIA6 could matter depends on whether native PDIA6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDIA6 is annotated at the cell surface, where native PDIA6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PDIA6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDIA6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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