Seroatlas · Human Serome Atlas

CCDC159

Coiled-coil domain-containing protein 159

Also known as: CC159_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C7I6
Gene: CCDC159
Ensembl: ENSG00000183401
Chromosome: 19
Canonical length: 297 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Predicted to be involved in spermatid development. Predicted to act upstream of or within several processes, including regulation of phosphatase activity; single fertilization; and sperm flagellum assembly. Predicted to be located in sperm head-tail coupling apparatus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>P0C7I6|CCDC159
     1  MGEHEQVKPL ETSSSKVKAK TIVMIPDSQK LLRCELESLK SQLQAQTKAF EFLNHSVTML
    61  EKESCLQQIK IQQLEEVLSP TGRQGEKEEH KWGMEQGRQE LYGALTQGLQ GLEKTLRDSE
   121  EMQRARTTRC LQLLAQEIRD SKKFLWEELE LVREEVTFIY QKLQAQEDEI SENLVNIQKM
   181  QKTQVKCRKI LTKMKQQGHE TAACPETEEI PQGASGCWKD DLQKELSDIW SAVHVLQNSI
   241  DSLTLCSGAC PKASSLRGHK GHQCLSPPLP SWDSDSDCDQ DLSQPPFSKS GRSFPPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC159 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

prostate: 45 nTPM
adrenal gland: 43 nTPM
spinal cord: 43 nTPM
testis: 42 nTPM
spleen: 41 nTPM
parathyroid gland: 37 nTPM

Single-cell type

late spermatids: 378 nCPM
early spermatids: 370 nCPM
cardiomyocytes: 199 nCPM
epicardial cells: 71 nCPM
late primary spermatocytes: 37 nCPM
epididymal principal cells: 34 nCPM

Immune cell

classical monocyte: 53 nTPM
basophil: 52 nTPM
intermediate monocyte: 46 nTPM
eosinophil: 39 nTPM
non-classical monocyte: 34 nTPM
myeloid DC: 32 nTPM

Brain region

white matter: 44 nTPM
cerebral cortex: 43 nTPM
medulla oblongata: 37 nTPM
thalamus: 36 nTPM
pons: 36 nTPM
basal ganglia: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.49
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

sperm head-tail coupling apparatus

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 159/163

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC159 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC159 as an antibody target. Whether an autoantibody or antibody against CCDC159 could matter depends on whether native CCDC159 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC159 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC159 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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