Seroatlas · Human Serome Atlas

OLFM3

Noelin-3

Also known as: NOE3, NOE3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96PB7
Gene
OLFM3
Ensembl
ENSG00000118733
Chromosome
1
Canonical length
478 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted in brain
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to be involved in signal transduction. Predicted to be located in Golgi apparatus; extracellular region; and synapse. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>Q96PB7|OLFM3
     1  MSPPLLKLGA VLSTMAMISN WMSQTLPSLV GLNTTRLSTP DTLTQISPKE GWQVYSSAQD
    61  PDGRCICTVV APEQNLCSRD AKSRQLRQLL EKVQNMSQSI EVLNLRTQRD FQYVLKMETQ
   121  MKGLKAKFRQ IEDDRKTLMT KHFQELKEKM DELLPLIPVL EQYKTDAKLI TQFKEEIRNL
   181  SAVLTGIQEE IGAYDYEELH QRVLSLETRL RDCMKKLTCG KLMKITGPVT VKTSGTRFGA
   241  WMTDPLASEK NNRVWYMDSY TNNKIVREYK SIADFVSGAE SRTYNLPFKW AGTNHVVYNG
   301  SLYFNKYQSN IIIKYSFDMG RVLAQRSLEY AGFHNVYPYT WGGFSDIDLM ADEIGLWAVY
   361  ATNQNAGNIV ISQLNQDTLE VMKSWSTGYP KRSAGESFMI CGTLYVTNSH LTGAKVYYSY
   421  STKTSTYEYT DIPFHNQYFH ISMLDYNARD RALYAWNNGH QVLFNVTLFH IIKTEDDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OLFM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 17 nTPM
  • cerebellum: 12 nTPM
  • retina: 6.8 nTPM
  • hypothalamus: 6.7 nTPM
  • basal ganglia: 5.8 nTPM
  • midbrain: 4.3 nTPM

Single-cell type

  • brain excitatory neurons: 503 nCPM
  • retinal amacrine cells: 385 nCPM
  • brain inhibitory neurons: 349 nCPM
  • other brain neurons: 196 nCPM
  • lactotrophs: 136 nCPM
  • respiratory ionocytes: 122 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 44 nTPM
  • cerebellum: 29 nTPM
  • white matter: 25 nTPM
  • thalamus: 22 nTPM
  • hypothalamus: 21 nTPM
  • basal ganglia: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0
gnomAD missense Z
1.61
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OLFM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OLFM3 as an antibody target. Whether an autoantibody or antibody against OLFM3 could matter depends on whether native OLFM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OLFM3 is annotated as secreted, so native OLFM3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OLFM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OLFM3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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