With No Lysine (K) Ser/Thr Protein Kinase
IPR050588
Definition
The WNK kinase family is involved in the regulation of electrolyte homeostasis, blood pressure, and cellular responses to osmotic stress. They act as molecular sensors and regulators of ion transport in various tissues, including the kidney and nervous system. WNK kinases phosphorylate and modulate the activity of downstream kinases and ion cotransporters, influencing ion influx and efflux. Some family members are implicated in developmental processes, such as embryogenesis and flowering time modulation. They also participate in signaling pathways, like the Wnt and photoperiod pathways, and may have roles in subcellular trafficking. Certain members possess a kinase domain predicted to be catalytically inactive, suggesting additional regulatory or scaffolding functions independent of kinase activity.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...