Neuralized homology repeat (NHR) domain

Definition

The neuralized homology repeat (NHR) domain is a module of ~160 amino acids, which has been identified as a tandem repeat in drosophila neuralized, a protein involved in development of the central and peripheral nervous system PMID:9519875. Several other fly, worm, and mammalian neuralized-like proteins were found to contain between one and six NHR domains associated with other modules, such as RING, SOCS, or SPRY [[cite:PMID:11779830], [cite:PMID:11731489]]. It has been suggested that the NHR domain is required for the localization of neuralized to the plasma membrane PMID:11696324. As it has been proposed that NHR domains do partly resemble SPRY domains, it is possible that NHR possess microtubule-binding functions, similar to those proposed for SPRY domains PMID:11731489.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• NEURL1
• NEURL1B
• NEURL2
• NEURL3
• NEURL4