Seroatlas · Human Serome Atlas

LYRM2

LYR motif-containing protein 2

Also known as: DJ122O8.2, LYRM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NU23
Gene: LYRM2
Ensembl: ENSG00000083099
Chromosome: 6
Canonical length: 88 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

88 residues, UniProt reviewed canonical sequence.

>Q9NU23|LYRM2
     1  MAASRLPPAT LTLKQFVRRQ QVLLLYRRIL QTIRQVPNDS DRKYLKDWAR EEFRRNKSAT
    61  EEDTIRMMIT QGNMQLKELE KTLALAKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LYRM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 24 nTPM
parathyroid gland: 21 nTPM
skeletal muscle: 20 nTPM
heart muscle: 16 nTPM
kidney: 16 nTPM
tongue: 16 nTPM

Single-cell type

fallopian tube ciliated cells: 111 nCPM
cytotrophoblasts: 110 nCPM
cardiomyocytes: 107 nCPM
late primary spermatocytes: 105 nCPM
respiratory ciliated cells: 90 nCPM
epididymal principal cells: 87 nCPM

Immune cell

non-classical monocyte: 34 nTPM
memory B-cell: 33 nTPM
naive B-cell: 31 nTPM
memory CD8 T-cell: 28 nTPM
NK-cell: 27 nTPM
naive CD4 T-cell: 27 nTPM

Brain region

spinal cord: 23 nTPM
hypothalamus: 23 nTPM
white matter: 23 nTPM
cerebral cortex: 23 nTPM
midbrain: 22 nTPM
basal ganglia: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: -0.47
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial respiratory chain complex I assembly

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LYRM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NDUFAB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LYRM2 as an antibody target. Whether an autoantibody or antibody against LYRM2 could matter depends on whether native LYRM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LYRM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LYRM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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