Seroatlas · Human Serome Atlas

NAA25

N-alpha-acetyltransferase 25, NatB auxiliary subunit

Also known as: C12orf30, FLJ13089, NAA25_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14CX7
Gene: NAA25
Ensembl: ENSG00000111300
Chromosome: 12
Canonical length: 972 aa
Protein class: Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

972 residues, UniProt reviewed canonical sequence.

>Q14CX7|NAA25
     1  MATRGHVQDP NDRRLRPIYD YLDNGNNKMA IQQADKLLKK HKDLHCAKVL KAIGLQRTGK
    61  QEEAFTLAQE VAALEPTDDN SLQALTILYR EMHRPELVTK LYEAAVKKVP NSEEYHSHLF
   121  MAYARVGEYK KMQQAGMALY KIVPKNPYYF WSVMSLIMQS ISAQDENLSK TMFLPLAERM
   181  VEKMVKEDKI EAEAEVELYY MILERLGKYQ EALDVIRGKL GEKLTSEIQS RENKCMAMYK
   241  KLSRWPECNA LSRRLLLKNS DDWQFYLTYF DSVFRLIEEA WSPPAEGEHS LEGEVHYSAE
   301  KAVKFIEDRI TEESKSSRHL RGPHLAKLEL IRRLRSQGCN DEYKLGDPEE LMFQYFKKFG
   361  DKPCCFTDLK VFVDLLPATQ CTKFINQLLG VVPLSTPTED KLALPADIRA LQQHLCVVQL
   421  TRLLGLYHTM DKNQKLSVVR ELMLRYQHGL EFGKTCLKTE LQFSDYYCLL AVHALIDVWR
   481  ETGDETTVWQ ALTLLEEGLT HSPSNAQFKL LLVRIYCMLG AFEPVVDLYS SLDAKHIQHD
   541  TIGYLLTRYA ESLGQYAAAS QSCNFALRFF HSNQKDTSEY IIQAYKYGAF EKIPEFIAFR
   601  NRLNNSLHFA QVRTERMLLD LLLEANISTS LAESIKSMNL RPEEDDIPWE DLRDNRDLNV
   661  FFSWDPKDRD VSEEHKKLSL EEETLWLRIR SLTLRLISGL PSLNHPVEPK NSEKTAENGV
   721  SSRIDILRLL LQQLEATLET GKRFIEKDIQ YPFLGPVPTR MGGFFNSGCS QCQISSFYLV
   781  NDIYELDTSG LEDTMEIQER IENSFKSLLD QLKDVFSKCK GDLLEVKDGN LKTHPTLLEN
   841  LVFFVETISV ILWVSSYCES VLRPYKLNLQ KKKKKKKETS IIMPPVFTSF QDYVTGLQTL
   901  ISNVVDHIKG LETHLIALKL EELILEDTSL SPEERKFSKT VQGKVQSSYL HSLLEMGELL
   961  KKRLETTKKL KI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAA25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 15 nTPM
retina: 14 nTPM
bone marrow: 9.2 nTPM
tongue: 9.2 nTPM
choroid plexus: 9.1 nTPM
cerebellum: 8.7 nTPM

Single-cell type

retinal pigment epithelial cells: 298 nCPM
choroid plexus epithelial cells: 256 nCPM
myonuclei: 249 nCPM
cone photoreceptor cells: 242 nCPM
rod photoreceptor cells: 176 nCPM
basal keratinocytes: 131 nCPM

Immune cell

naive CD4 T-cell: 4.2 nTPM
naive CD8 T-cell: 4.1 nTPM
MAIT T-cell: 3.7 nTPM
plasmacytoid DC: 3.7 nTPM
myeloid DC: 3.5 nTPM
memory CD4 T-cell: 3 nTPM

Brain region

choroid plexus: 23 nTPM
white matter: 22 nTPM
pons: 22 nTPM
cerebral cortex: 20 nTPM
cerebellum: 19 nTPM
medulla oblongata: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.11
gnomAD pLI: 1
gnomAD missense Z: 3.45
DepMap mean gene effect: -0.78
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cytoskeleton organization

Molecular functions

acetyltransferase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
N-alpha-acetyltransferase 25, NatB auxiliary subunit
N-acetyltransferase B complex (NatB) non catalytic subunit

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAA25 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NAA20

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAA25 as an antibody target. Whether an autoantibody or antibody against NAA25 could matter depends on whether native NAA25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAA25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAA25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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