Glycoside hydrolase family 31, TIM barrel domain

Definition

This entry corresponds to the second domain of family 31 enzymes and adopts a TIM-barrel fold. O-Glycosyl hydrolases ([ec:3.2.1.]) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [[cite:PMID:7624375], [cite:PMID:8535779]]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website. Glycoside hydrolase family 31 [cazy:GH31] comprises enzymes with several known activities; alpha-glucosidase ([ec:3.2.1.20]), alpha-galactosidase ([ec:3.2.1.22]); glucoamylase ([ec:3.2.1.3]), sucrase-isomaltase ([ec:3.2.1.48]); isomaltase ([ec:3.2.1.10]); alpha-xylosidase ([ec:3.2.1]); alpha-glucan lyase ([ec:4.2.2.13]).

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• GAA
• GANAB
• GANC
• MGAM
• MGAM2
• MYORG
• SI