ESPNL

Protein identityUniProt · HPA

UniProt accession

Q6ZVH7

Gene

ESPNL

Ensembl

ENSG00000144488

Chromosome

2

Canonical length

1005 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly and sensory perception of sound. Predicted to be located in stereocilium tip. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1005 residues, UniProt reviewed canonical sequence.

>Q6ZVH7|ESPNL
     1  MEKQRALVAA KDGDVATLER LLEAGALGPG ITDALGAGLV HHATRAGHLD CVKFLVQRAQ
    61  LPGNQRAHNG ATPAHDAAAT GSLAELCWLV REGGCGLQDQ DASGVSPLHL AARFGHPVLV
   121  EWLLHEGHSA TLETREGARP LHHAAVSGDL TCLKLLTAAH GSSVNRRTRS GASPLYLACQ
   181  EGHLHLAQFL VKDCGADVHL RALDGMSALH AAAARGHYSL VVWLVTFTDI GLTARDNEGA
   241  TALHFAARGG HTPILDRLLL MGTPILRDSW GGTPLHDAAE NGQMECCQTL VSHHVDPSLR
   301  DEDGYTAADL AEYHGHRDCA QYLREVAQPV PLLMTPPPPP FPPPPLLATR RSLEDGRRGG
   361  PGPGNPSPMS LSPAWPGHPD QPLPREQMTS PAPPRIITSA TADPEGTETA LAGDTSDGLA
   421  ALQLDGLPSG DIDGLVPTRD ERGQPIPEWK RQVMVRKLQA RLGAESSAEA QDNGGSSGPT
   481  EQAAWRYSQT HQAILGPFGE LLTEDDLVYL EKQIADLQLR RRCQEYESEL GRLAAELQAL
   541  LPEPLVSITV NSHFLPRAPG LEVEEASIPA AEPAGSAEAS EVAPGVQPLP FWCSHISRLV
   601  RSLSLLLKGV HGLVQGDEKP STRPLQDTCR EASASPPRSE AQRQIQEWGV SVRTLRGNFE
   661  SASGPLCGFN PGPCEPGAQH RQCLSGCWPA LPKPRSGLAS GEPRPGDTEE ASDSGISCEE
   721  VPSEAGAAAG PDLASLRKER IIMLFLSHWR RSAYTPALKT VACRTLGARH AGLRGQEAAR
   781  SPGPPSPPSE GPRLGHLWQQ RSTITHLLGN WKAIMAHVPA RQLRRLSRQP RGALSPEQFL
   841  PHVDGAPVPY SSLSLDLFML GYFQLLECDL PAEERKLRHL LCFEVFEHLG THGWEAVRAF
   901  HKAVTDEVAA GRRAWTDGFE DIKARFFGSS QRPAWDTEPG RKSGLTLLGP LPHAAVPCSG
   961  PEPTAQRLGS RSQQGSFNGE DICGYINRSF AFWKEKEAEM FNFGE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ESPNL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.44

Highest tissue expression

4.2 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.94

gnomAD pLI

0

gnomAD missense Z

0.49

DepMap mean gene effect

-0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin filament bundle assembly
• sensory perception of sound

Molecular functions

• actin filament binding

Cellular components

• cytoplasm
• stereocilium tip

Protein domainsUniProt · Pfam · InterPro

• Ankyrin repeat
• Ankyrin repeat-containing domain superfamily
• Espin and Espin-like domain-containing protein
• Ankyrin repeats (3 copies)
• Ankyrin repeats (many copies)

KeywordsUniProt

• Actin-binding
• ANK repeat
• Cell projection
• Coiled coil
• Hearing
• Repeat

InteractionsUniProt · HPA

Protein binding partners of ESPNL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MYO3A
• MYO3B