Seroatlas · Human Serome Atlas

MC5R

Melanocortin receptor 5

Also known as: MC5R_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P33032
Gene: MC5R
Ensembl: ENSG00000176136
Chromosome: 18
Canonical length: 325 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>P33032|MC5R
     1  MNSSFHLHFL DLNLNATEGN LSGPNVKNKS SPCEDMGIAV EVFLTLGVIS LLENILVIGA
    61  IVKNKNLHSP MYFFVCSLAV ADMLVSMSSA WETITIYLLN NKHLVIADAF VRHIDNVFDS
   121  MICISVVASM CSLLAIAVDR YVTIFYALRY HHIMTARRSG AIIAGIWAFC TGCGIVFILY
   181  SESTYVILCL ISMFFAMLFL LVSLYIHMFL LARTHVKRIA ALPGASSARQ RTSMQGAVTV
   241  TMLLGVFTVC WAPFFLHLTL MLSCPQNLYC SRFMSHFNMY LILIMCNSVM DPLIYAFRSQ
   301  EMRKTFKEII CCRGFRIACS FPRRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MC5R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 2.5 nTPM

Expression across tissuesHPA

Tissue

epididymis: 2.5 nTPM
thymus: 1 nTPM
esophagus: 0.5 nTPM
parathyroid gland: 0.3 nTPM
retina: 0.3 nTPM
skin: 0.3 nTPM

Single-cell type

late spermatids: 9 nCPM
early spermatids: 7 nCPM
medullary thymic epithelial cells: 4.8 nCPM
esophageal apical cells: 2.4 nCPM
epididymal principal cells: 1.2 nCPM
esophageal suprabasal cells: 1.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 2 nTPM
basal ganglia: 1.6 nTPM
cerebellum: 1.6 nTPM
cerebral cortex: 1.6 nTPM
choroid plexus: 1.6 nTPM
amygdala: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MC5R in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MC5R as an antibody target. Whether an autoantibody or antibody against MC5R could matter depends on whether native MC5R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MC5R is annotated at the cell surface, where native MC5R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MC5R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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