Seroatlas · Human Serome Atlas

BBOF1

Basal body-orientation factor 1

Also known as: BBOF1_HUMAN, C14orf45, CCDC176, FBB10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8ND07
Gene
BBOF1
Ensembl
ENSG00000119636
Chromosome
14
Canonical length
529 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Centriolar satellite,Cytosol

OverviewNCBI Gene

Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within several processes, including cilium movement involved in cell motility; negative regulation of microtubule depolymerization; and protein stabilization. Predicted to be located in axoneme; ciliary basal body; and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

529 residues, UniProt reviewed canonical sequence.

>Q8ND07|BBOF1
     1  MPSKGKDKKK GKSKGKDTKK LIKTDESVVD RAKANASLWE ARLEVTELSR IKYRDTSRIL
    61  AKSNEDLKKK QCKMEKDIMS VLSYLKKQDQ EKDNMIEKLK QQLNETKEKA QEEKDKLEQK
   121  YTRQINELEG QFHQKAKEIG MIHTELKAVR QFQKRKIQVE RELDDLKENL RNTERIHQET
   181  LRRLESRFFE EKHRLEQEAE KKIIMLAERA HHEAIVQLND AGRNVFKEND YLQKALAYHL
   241  KETDALQKNS QKLQESHTLL LHQKEINDLL VKEKIMQLVQ QRSQIQTLQK KVVNLETALS
   301  YMTKEFESEV LKLQQHAMIE NQAGQVEIDK LQHLLQMKDR EMNRVKKLAK NILDERTEVE
   361  RFFLDALHQV KQQILISRKH YKQIAQAAFN LKMRAACTGR TEYPKIRTFD GREHSTNSVN
   421  QDLLEAEKWT HIEGNVDIGD LTWEQKEKVL RLLFAKMNGC PSRKYNQSSR PPVPDYVVSD
   481  SGETKEFGDE SKLQDKIFIT QQIAISDSSG EVVLPTIPKE PQESDTGTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BBOF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • testis: 36 nTPM
  • choroid plexus: 25 nTPM
  • retina: 23 nTPM
  • fallopian tube: 21 nTPM
  • epididymis: 14 nTPM
  • thyroid gland: 12 nTPM

Single-cell type

  • respiratory ciliated cells: 421 nCPM
  • late primary spermatocytes: 418 nCPM
  • endometrial ciliated cells: 353 nCPM
  • epididymal efferent duct ciliated cells: 324 nCPM
  • fallopian tube ciliated cells: 305 nCPM
  • ependymal cells: 265 nCPM

Immune cell

  • plasmacytoid DC: 2.4 nTPM
  • naive CD4 T-cell: 1.9 nTPM
  • MAIT T-cell: 1.8 nTPM
  • gdT-cell: 1.5 nTPM
  • naive CD8 T-cell: 1.5 nTPM
  • memory CD4 T-cell: 1.4 nTPM

Brain region

  • choroid plexus: 29 nTPM
  • medulla oblongata: 16 nTPM
  • midbrain: 16 nTPM
  • spinal cord: 13 nTPM
  • cerebral cortex: 12 nTPM
  • pons: 9.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.27
gnomAD pLI
0
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BBOF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BBOF1 as an antibody target. Whether an autoantibody or antibody against BBOF1 could matter depends on whether native BBOF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BBOF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BBOF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BBOF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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