Seroatlas · Human Serome Atlas

MND1

Meiotic nuclear division protein 1 homolog

Also known as: GAJ, MND1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWT6
Gene: MND1
Ensembl: ENSG00000121211
Chromosome: 4
Canonical length: 205 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q9BWT6|MND1
     1  MSKKKGLSAE EKRTRMMEIF SETKDVFQLK DLEKIAPKEK GITAMSVKEV LQSLVDDGMV
    61  DCERIGTSNY YWAFPSKALH ARKHKLEVLE SQLSEGSQKH ASLQKSIEKA KIGRCETEER
   121  TRLAKELSSL RDQREQLKAE VEKYKDCDPQ VVEEIRQANK VAKEAANRWT DNIFAIKSWA
   181  KRKFGFEENK IDRTFGIPED FDYID

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MND1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

thymus: 25 nTPM
testis: 15 nTPM
tonsil: 13 nTPM
bone marrow: 13 nTPM
lymph node: 11 nTPM
rectum: 4.8 nTPM

Single-cell type

oligodendrocytes: 45 nCPM
renal collecting duct intercalated cells: 11 nCPM
loop of henle epithelial cells: 8 nCPM
oligodendrocyte progenitor cells: 6 nCPM
other brain neurons: 5.7 nCPM
distal convoluted tubule cells: 5.2 nCPM

Immune cell

T-reg: 1.7 nTPM
myeloid DC: 1.3 nTPM
NK-cell: 0.4 nTPM
memory CD4 T-cell: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM
gdT-cell: 0.1 nTPM

Brain region

white matter: 2.1 nTPM
medulla oblongata: 1.5 nTPM
hypothalamus: 1.3 nTPM
thalamus: 1.3 nTPM
basal ganglia: 1.2 nTPM
pons: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: 0.41
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

double-stranded DNA binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Winged helix DNA-binding domain superfamily
Leucine zipper with capping helix domain
Leucine zipper with capping helix domain
Meiotic nuclear division protein 1
Mnd1, HTH domain
Mnd1 HTH domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MND1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MND1 as an antibody target. Whether an autoantibody or antibody against MND1 could matter depends on whether native MND1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MND1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MND1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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