Seroatlas · Human Serome Atlas

MGAT4D

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D

Also known as: GnT1IP, MGT4D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NG13
Gene: MGAT4D
Ensembl: ENSG00000205301
Chromosome: 4
Canonical length: 374 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>A6NG13|MGAT4D
     1  MRTKQVNLLI TLVAVALFSF SCFSIYRITQ TNNQLINCRN HILEFKENML HLRNKTEKNT
    61  QEMMKVLNRM KYEITKREIL SGNLVAQKAD ILNKNETVSN TFEDLKFFFP HLRKEGRIYP
   121  DVIIGKGKTG VSFALGISTV NRGNYSYLKQ TLTSVVSRMT LSQEKDSVVI VLVADSNEDY
   181  LHSVVKMITK KFKRQVRSGS LEVISIPAFL YSSMLNAKHL AEASQKLASW RIKQVLDFCI
   241  LLLYAQPKAK YYLQLEDDII AKEMYFTKIT DFVGNISSNN WFFIEFSMLG FIGKLFRSED
   301  LTHFVRFFLM FYKEKPIDWL LNDIFQVKVC DAGEDLRNCM KRKKQIRIQY KPSLFQHVGI
   361  HSSFPRKEQY EKKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MGAT4D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

testis: 21 nTPM
epididymis: 0.5 nTPM
fallopian tube: 0.3 nTPM
liver: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late primary spermatocytes: 184 nCPM
early primary spermatocytes: 63 nCPM
late spermatids: 52 nCPM
ependymal cells: 33 nCPM
early spermatids: 23 nCPM
respiratory ciliated cells: 13 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 0.3 nTPM
hypothalamus: 0.2 nTPM
medulla oblongata: 0.2 nTPM
pons: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: 0.12
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

acetylglucosaminyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MGAT4D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MGAT4D as an antibody target. Whether an autoantibody or antibody against MGAT4D could matter depends on whether native MGAT4D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MGAT4D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MGAT4D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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