Seroatlas · Human Serome Atlas

MACROD1

ADP-ribose glycohydrolase MACROD1

Also known as: LRP16, MACD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQ69
Gene: MACROD1
Ensembl: ENSG00000133315
Chromosome: 11
Canonical length: 325 aa
Protein class: Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables ADP-ribosylglutamate hydrolase activity and deacetylase activity. Involved in DNA damage response; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q9BQ69|MACROD1
     1  MSLQSRLSGR LAQLRAAGQL LVPPRPRPGH LAGATRTRSS TCGPPAFLGV FGRRARTSAG
    61  VGAWGAAAVG RTAGVRTWAP LAMAAKVDLS TSTDWKEAKS FLKGLSDKQR EEHYFCKDFV
   121  RLKKIPTWKE MAKGVAVKVE EPRYKKDKQL NEKISLLRSD ITKLEVDAIV NAANSSLLGG
   181  GGVDGCIHRA AGPLLTDECR TLQSCKTGKA KITGGYRLPA KYVIHTVGPI AYGEPSASQA
   241  AELRSCYLSS LDLLLEHRLR SVAFPCISTG VFGYPCEAAA EIVLATLREW LEQHKDKVDR
   301  LIICVFLEKD EDIYRSRLPH YFPVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MACROD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 270 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 270 nTPM
heart muscle: 105 nTPM
tongue: 55 nTPM
kidney: 54 nTPM
liver: 48 nTPM
pancreas: 47 nTPM

Single-cell type

myonuclei: 328 nCPM
parietal cells: 133 nCPM
early spermatids: 118 nCPM
paneth cells: 101 nCPM
enteric transient amplifying cells: 98 nCPM
enteric stem cells: 95 nCPM

Immune cell

gdT-cell: 0.4 nTPM
MAIT T-cell: 0.4 nTPM
memory CD4 T-cell: 0.4 nTPM
intermediate monocyte: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM

Brain region

hypothalamus: 17 nTPM
cerebral cortex: 16 nTPM
pons: 16 nTPM
midbrain: 14 nTPM
medulla oblongata: 14 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.57
gnomAD missense Z: 0.79
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MACROD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MACROD1 as an antibody target. Whether an autoantibody or antibody against MACROD1 could matter depends on whether native MACROD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MACROD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MACROD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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