Seroatlas · Human Serome Atlas

LRRC49

Leucine-rich repeat-containing protein 49

Also known as: CSTPP2, FLJ20156, LRC49_HUMAN, PGs4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IUZ0
Gene: LRRC49
Ensembl: ENSG00000137821
Chromosome: 15
Canonical length: 686 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Located in centriolar satellite. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

686 residues, UniProt reviewed canonical sequence.

>Q8IUZ0|LRRC49
     1  MIPGKYRSVS GRAANNVNCG LHLVIQTSSL PEKNKVEFKL NKDTSSFPGR LLQHDLERNY
    61  SSRQGDHINL VSSSLSSFPI LQRSSEEKIL YSDRLSLERQ KLTVCPIING EDHLRLLNFQ
   121  HNFITRIQNI SNLQKLISLD LYDNQIEEIS GLSTLRCLRV LLLGKNRIKK ISNLENLKSL
   181  DVLDLHGNQI TKIENINHLC ELRVLNLARN FLSHVDNLNG LDSLTELNLR HNQITFVRDV
   241  DNLPCLQHLF LSFNNISSFD SVSCLADSSS LSDITFDGNP IAQESWYKHT VLQNMMQLRQ
   301  LDMKRITEEE RRMASVLAKK EEEKKRESHK QSLLKEKKRL TINNVARQWD LQQQRVANIA
   361  TNEDRKDSDS PQDPCQIDGS TLSAFPEETG PLDSGLNNAL QGLSVIDTYL VEVDGDTLSL
   421  YGSGALESLD RNWSVQTAGM ITTVSFTFIE FDEIVQVLPK LKIKFPNSLH LKFKETNLVM
   481  LQQFNALAQL RRIDQLTIDP QGNPVVNFTL WKYYVLFRLS HFSMQKINGT EVTQNDMIMA
   541  ERLFGILAHV ASSELPQYRL ISILGDARKK QFRYLLESKG KKPGIINEEN NDSKRLVGEN
   601  TNRATLNYTT RDFYNEKLEE IKEKKKFCKT YIEDLVKEAT EINMKNEALQ KLWPQMFIEL
   661  VRDAVIEIRN KNSYMKLCLQ QITDQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC49 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 53 nTPM
epididymis: 28 nTPM
retina: 25 nTPM
cerebellum: 12 nTPM
testis: 11 nTPM
basal ganglia: 10 nTPM

Single-cell type

thyrotrophs: 298 nCPM
retinal bipolar cells: 249 nCPM
lactotrophs: 236 nCPM
somatotrophs: 213 nCPM
ependymal cells: 187 nCPM
late spermatids: 176 nCPM

Immune cell

intermediate monocyte: 0.3 nTPM
MAIT T-cell: 0.3 nTPM
basophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

thalamus: 45 nTPM
cerebellum: 35 nTPM
pons: 33 nTPM
cerebral cortex: 29 nTPM
medulla oblongata: 29 nTPM
hypothalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0
gnomAD missense Z: 1.16
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC49 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC49 as an antibody target. Whether an autoantibody or antibody against LRRC49 could matter depends on whether native LRRC49 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC49 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC49 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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