CSTPP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1
Also known as: C11orf49, CSTP1_HUMAN, FLJ22210, MGC4707
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H6J7
- Gene
- CSTPP1
- Ensembl
- ENSG00000149179
- Chromosome
- 11
- Canonical length
- 331 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Primary cilium,Basal body,Cytosol
OverviewNCBI Gene
Enables protein-macromolecule adaptor activity. Involved in regulation of protein complex stability. Is active in centriolar satellite. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
331 residues, UniProt reviewed canonical sequence.
>Q9H6J7|CSTPP1
1 MLSPERLALP DYEYLAQRHV LTYMEDAVCQ LLENREDISQ YGIARFFTEY FNSVCQGTHI
61 LFREFSFVQA TPHNRVSFLR AFWRCFRTVG KNGDLLTMKE YHCLLQLLCP DFPLELTQKA
121 ARIVLMDDAM DCLMSFSDFL FAFQIQFYYS EFLDSVAAIY EDLLSGKNPN TVIVPTSSSG
181 QHRQRPALGG AGTLEGVEAS LFYQCLENLC DRHKYSCPPP ALVKEALSNV QRLTFYGFLM
241 ALSKHRGINQ ALGALPDKGD LMHDPAMDEE LERLLAQVPG LVNSVTASPE ASCLPSRTPP
301 RVGSPWRPLH HSRKVDGESD GSTEETDESE TLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CSTPP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 61 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 61 nTPM
- choroid plexus: 50 nTPM
- basal ganglia: 45 nTPM
- hypothalamus: 45 nTPM
- amygdala: 38 nTPM
- hippocampal formation: 36 nTPM
Single-cell type
- choroid plexus epithelial cells: 592 nCPM
- respiratory ciliated cells: 555 nCPM
- ependymal cells: 461 nCPM
- pituicytes/fscs: 451 nCPM
- thyrotrophs: 399 nCPM
- somatotrophs: 386 nCPM
Immune cell
- NK-cell: 25 nTPM
- myeloid DC: 25 nTPM
- memory B-cell: 24 nTPM
- MAIT T-cell: 23 nTPM
- memory CD8 T-cell: 23 nTPM
- plasmacytoid DC: 22 nTPM
Brain region
- midbrain: 54 nTPM
- hypothalamus: 52 nTPM
- thalamus: 50 nTPM
- basal ganglia: 49 nTPM
- cerebral cortex: 49 nTPM
- hippocampal formation: 46 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.29
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Centriolar satellite-associated tubulin polyglutamylase complex regulator 1
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CSTPP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CSTPP1 as an antibody target. Whether an autoantibody or antibody against CSTPP1 could matter depends on whether native CSTPP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CSTPP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CSTPP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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