Seroatlas · Human Serome Atlas

TPGS2

Tubulin polyglutamylase complex subunit 2

Also known as: C18orf10, DKFZP586M1523, HsT3006, PGs2, TPGS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68CL5
Gene: TPGS2
Ensembl: ENSG00000134779
Chromosome: 18
Canonical length: 300 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein that is a component of the neuronal polyglutamylase complex, which plays a role in post-translational addition of glutamate residues to C-terminal tubulin tails. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

300 residues, UniProt reviewed canonical sequence.

>Q68CL5|TPGS2
     1  MEEEASSPGL GCSKPHLEKL TLGITRILES SPGVTEVTII EKPPAERHMI SSWEQKNNCV
    61  MPEDVKNFYL MTNGFHMTWS VKLDEHIIPL GSMAINSISK LTQLTQSSMY SLPNAPTLAD
   121  LEDDTHEASD DQPEKPHFDS RSVIFELDSC NGSGKVCLVY KSGKPALAED TEIWFLDRAL
   181  YWHFLTDTFT AYYRLLITHL GLPQWQYAFT SYGISPQAKQ WFSMYKPITY NTNLLTEETD
   241  SFVNKLDPSK VFKSKNKIVI PKKKGPVQPA GGQKGPSGPS GPSTSSTSKS SSGSGNPTRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPGS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 276 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 276 nTPM
testis: 189 nTPM
midbrain: 98 nTPM
thymus: 94 nTPM
spinal cord: 91 nTPM
hypothalamus: 83 nTPM

Single-cell type

late spermatids: 1,756 nCPM
late primary spermatocytes: 540 nCPM
early spermatids: 450 nCPM
cardiomyocytes: 328 nCPM
choroid plexus epithelial cells: 219 nCPM
extravillous trophoblasts: 211 nCPM

Immune cell

basophil: 267 nTPM
T-reg: 95 nTPM
eosinophil: 90 nTPM
non-classical monocyte: 62 nTPM
total PBMC: 53 nTPM
NK-cell: 53 nTPM

Brain region

choroid plexus: 320 nTPM
pons: 158 nTPM
midbrain: 152 nTPM
hypothalamus: 136 nTPM
medulla oblongata: 130 nTPM
cerebral cortex: 108 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: -0.03
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Knr4/Smi1-like domain
Knr4/Smi1-like domain superfamily
Tubulin polyglutamylase complex subunit 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TPGS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPGS2 as an antibody target. Whether an autoantibody or antibody against TPGS2 could matter depends on whether native TPGS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPGS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPGS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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