Seroatlas · Human Serome Atlas

TPGS1

Tubulin polyglutamylase complex subunit 1

Also known as: C19orf20, GTRGEO22, PGs1, TPGS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZTW0
Gene
TPGS1
Ensembl
ENSG00000141933
Chromosome
19
Canonical length
290 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable microtubule binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within several processes, including adult behavior; chemical synaptic transmission; and protein polyglutamylation. Located in centrosome. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

290 residues, UniProt reviewed canonical sequence.

>Q6ZTW0|TPGS1
     1  MAAVEKRRQA VPPPAGFTDS GRQSVSRAAG AAESEEDFLR QVGVTEMLRA ALLKVLEARP
    61  EEPIAFLAHY FENMGLRSPV NGGAGEPPGQ LLLQQQRLGR ALWHLRLAHH SQRAAFNNNV
   121  SVAYECLSAG GRRKRPGLDG RTYSELLRRI CRDGQAPEEV VAPLLRKVQC RDHEAVPLSV
   181  FRAGTLTCFV LLEFVARAGA LFQLLEDSAA AVADRRVGQA VLDTLEGALQ ASDAAAPARF
   241  LEAGSRLGPD SLALALDRAV GGRRPSAPMT REEFLERAAA LFIAKVKPVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPGS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 23 nTPM
  • cerebral cortex: 21 nTPM
  • amygdala: 19 nTPM
  • blood vessel: 19 nTPM
  • basal ganglia: 17 nTPM
  • kidney: 17 nTPM

Single-cell type

  • epididymal principal cells: 84 nCPM
  • enterocytes: 69 nCPM
  • epididymal efferent duct absorptive cells: 69 nCPM
  • esophageal apical cells: 66 nCPM
  • esophageal suprabasal cells: 66 nCPM
  • epididymal clear cells: 61 nCPM

Immune cell

  • naive B-cell: 5.3 nTPM
  • eosinophil: 3.9 nTPM
  • T-reg: 3.7 nTPM
  • memory B-cell: 2.7 nTPM
  • memory CD8 T-cell: 1.7 nTPM
  • naive CD4 T-cell: 1 nTPM

Brain region

  • medulla oblongata: 28 nTPM
  • white matter: 26 nTPM
  • midbrain: 26 nTPM
  • thalamus: 25 nTPM
  • cerebellum: 25 nTPM
  • hippocampal formation: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TPGS1.

Disease | ImmuneIEDB

Conditions an epitope on TPGS1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.56
gnomAD pLI
0.06
gnomAD missense Z
1.33
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Tubulin polyglutamylase complex subunit 1
  • Tubulin polyglutamylase complex subunit 1, dimerization/docking domain
  • Tubulin polyglutamylase complex subunit 1-like, C-terminal
  • Tubulin polyglutamylase complex subunit 1-like, C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TPGS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPGS1 as an antibody target. Whether an autoantibody or antibody against TPGS1 could matter depends on whether native TPGS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPGS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPGS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TPGS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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