Glycoprotein hormone receptor family
IPR002131
Definition
Glycoprotein hormones (or gonadotropins) are protein hormones, that includes the mammalian hormones follicle-stimulating hormone (FSH, also known as follitropin), luteinizing hormone (LH, also known as lutropin), thyroid-stimulating hormone (TSH, also known as thyrotropin) and human chorionic gonadotropin (hCG). These hormones are central to the complex endocrine system that regulates normal growth, sexual development, and reproductive function PMID:6177696. The hormones FSH, LH and TSH are secreted by the anterior pituitary gland [[cite:PMID:6267989], [cite:PMID:1445230]], while the choriogonadotropins are secreted by the placenta PMID:19171054. Glycoprotein hormone receptors are members the rhodopsin-like G-protein coupled receptor (GPCR) family. They function as receptors for the pituitary hormones thyrotropin (TSH receptor), follitropin (FSH receptor) and lutropin (LH receptor). In mammals the LH receptor is also the receptor for the placental hormone, human chorionic gonadotropin (hCG), so is denominated as a lutropin-choriogonadotropic hormone receptor (LHCG receptor). The receptors share close sequence similarity, and are characterised by large extracellular domains believed to be involved in hormone binding via leucine-rich repeats (LRR) PMID:8747461. This entry represents the glycoprotein hormone receptor family, which includes the follicle stimulating hormone receptor, lutropin-choriogonadotropic hormone receptor and the thyroid stimulating hormone receptor.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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