Seroatlas · Human Serome Atlas

AIF1

Allograft inflammatory factor 1

Also known as: AIF-1, AIF1_HUMAN, Em:AF129756.17, IBA1, IRT-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P55008
Gene: AIF1
Ensembl: ENSG00000204472
Chromosome: 6
Canonical length: 147 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>P55008|AIF1
     1  MSQTRDLQGG KAFGLLKAQQ EERLDEINKQ FLDDPKYSSD EDLPSKLEGF KEKYMEFDLN
    61  GNGDIDIMSL KRMLEKLGVP KTHLELKKLI GEVSSGSGET FSYPDFLRMM LGKRSAILKM
   121  ILMYEEKARE KEKPTGPPAK KAISELP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AIF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 358 nTPM

Expression across tissuesHPA

Tissue

spleen: 358 nTPM
bone marrow: 222 nTPM
appendix: 172 nTPM
lymph node: 109 nTPM
spinal cord: 106 nTPM
placenta: 103 nTPM

Single-cell type

hofbauer cells: 2,383 nCPM
kupffer cells: 2,213 nCPM
monocytes: 1,381 nCPM
cdc: 903 nCPM
macrophages: 841 nCPM
neutrophils: 701 nCPM

Immune cell

non-classical monocyte: 7,785 nTPM
intermediate monocyte: 6,564 nTPM
total PBMC: 4,455 nTPM
classical monocyte: 3,837 nTPM
neutrophil: 2,963 nTPM
myeloid DC: 2,047 nTPM

Brain region

medulla oblongata: 56 nTPM
white matter: 47 nTPM
pons: 37 nTPM
spinal cord: 29 nTPM
thalamus: 28 nTPM
choroid plexus: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AIF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LCP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AIF1 as an antibody target. Whether an autoantibody or antibody against AIF1 could matter depends on whether native AIF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AIF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AIF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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