Seroatlas · Human Serome Atlas

LACC1

Purine nucleoside phosphorylase LACC1

Also known as: C13orf31, FAMIN, FLJ38725, LACC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IV20
Gene
LACC1
Ensembl
ENSG00000179630
Chromosome
13
Canonical length
430 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes an oxidoreductase that promotes fatty-acid oxidation, with concomitant inflammasome activation, mitochondrial and NADPH-oxidase-dependent reactive oxygen species production, and bactericidal activity of macrophages. The encoded protein forms a complex with fatty acid synthase on peroxisomes and is thought to be modulated by peroxisome proliferator-activated receptor signaling events. Naturally occurring mutations in this gene are associated with inflammatory bowel disease, Behcet's disease, leprosy, ulcerative colitis, early-onset Crohn's disease, and systemic juvenile idiopathic arthritis. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

430 residues, UniProt reviewed canonical sequence.

>Q8IV20|LACC1
     1  MAEAVLIDLF GLKLNSQKNC HQTLLKTLNA VQYHHAAKAK FLCIMCCSNI SYERDGEQDN
    61  CEIETSNGLS ALLEEFEIVS CPSMAATLYT IKQKIDEKNL SSIKVIVPRH RKTLMKAFID
   121  QLFTDVYNFE FEDLQVTFRG GLFKQSIEIN VITAQELRGI QNEIETFLRS LPALRGKLTI
   181  ITSSLIPDIF IHGFTTRTGG ISYIPTLSSF NLFSSSKRRD PKVVVQENLR RLANAAGFNV
   241  EKFYRIKTHH SNDIWIMGRK EPDSYDGITT NQRGVTIAAL GADCIPIVFA DPVKKACGVA
   301  HAGWKGTLLG VAMATVNAMI AEYGCSLEDI VVVLGPSVGP CCFTLPRESA EAFHNLHPAC
   361  VQLFDSPNPC IDIRKATRIL LEQGGILPQN IQDQNQDLNL CTSCHPDKFF SHVRDGLNFG
   421  TQIGFISIKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LACC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • midbrain: 17 nTPM
  • small intestine: 13 nTPM
  • spinal cord: 13 nTPM
  • rectum: 13 nTPM
  • hippocampal formation: 12 nTPM
  • appendix: 12 nTPM

Single-cell type

  • cardiomyocytes: 64 nCPM
  • epicardial cells: 18 nCPM
  • monocytes: 10 nCPM
  • macrophages: 8.6 nCPM
  • cdc: 8.4 nCPM
  • adipocytes: 7.5 nCPM

Immune cell

  • non-classical monocyte: 8 nTPM
  • intermediate monocyte: 5.2 nTPM
  • eosinophil: 3.1 nTPM
  • classical monocyte: 3 nTPM
  • myeloid DC: 2.7 nTPM
  • basophil: 1 nTPM

Brain region

  • white matter: 47 nTPM
  • basal ganglia: 37 nTPM
  • thalamus: 27 nTPM
  • cerebral cortex: 23 nTPM
  • pons: 23 nTPM
  • midbrain: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LACC1.

Disease | AllUniProt

Conditions LACC1 is implicated in, by any mechanism.

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 76 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Juvenile arthritis due to defect in LACC1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
1.64
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Multi-copper polyphenol oxidoreductase
  • Cytotoxic necrotizing factor-like, catalytic
  • Multi-copper polyphenol oxidoreductase superfamily
  • Multi-copper polyphenol oxidoreductase laccase

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LACC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LACC1 as an antibody target. Whether an autoantibody or antibody against LACC1 could matter depends on whether native LACC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LACC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LACC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LACC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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