Seroatlas · Human Serome Atlas

OSTC

Oligosaccharyltransferase complex subunit OSTC

Also known as: DC2, OSTC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRP0
Gene: OSTC
Ensembl: ENSG00000198856
Chromosome: 4
Canonical length: 149 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables protein-macromolecule adaptor activity. Involved in co-translational protein modification and protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex A. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>Q9NRP0|OSTC
     1  METLYRVPFL VLECPNLKLK KPPWLHMPSA MTVYALVVVS YFLITGGIIY DVIVEPPSVG
    61  SMTDEHGHQR PVAFLAYRVN GQYIMEGLAS SFLFTMGGLG FIILDRSNAP NIPKLNRFLL
   121  LFIGFVCVLL SFFMARVFMR MKLPGYLMG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OSTC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 181 nTPM

Expression across tissuesHPA

Tissue

liver: 181 nTPM
epididymis: 170 nTPM
pancreas: 129 nTPM
cervix: 111 nTPM
ovary: 102 nTPM
thyroid gland: 99 nTPM

Single-cell type

extravillous trophoblasts: 834 nCPM
decidual stromal cells: 599 nCPM
epididymal principal cells: 462 nCPM
syncytiotrophoblasts: 432 nCPM
migrating cytotrophoblasts: 423 nCPM
esophageal apical cells: 417 nCPM

Immune cell

plasmacytoid DC: 376 nTPM
total PBMC: 227 nTPM
myeloid DC: 204 nTPM
MAIT T-cell: 203 nTPM
NK-cell: 153 nTPM
basophil: 147 nTPM

Brain region

choroid plexus: 41 nTPM
white matter: 23 nTPM
thalamus: 23 nTPM
hypothalamus: 23 nTPM
medulla oblongata: 22 nTPM
spinal cord: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0.02
gnomAD missense Z: 1
DepMap mean gene effect: -0.4
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-macromolecule adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

MAGT1/OST3/OST6
OST3 / OST6 family, transporter family
Oligosaccharyltransferase complex subunit OSTC

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OSTC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OSTC as an antibody target. Whether an autoantibody or antibody against OSTC could matter depends on whether native OSTC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OSTC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OSTC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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