Seroatlas · Human Serome Atlas

CCNJL

Cyclin-J-like protein

Also known as: CCNJL_HUMAN, FLJ14166

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IV13
Gene: CCNJL
Ensembl: ENSG00000135083
Chromosome: 5
Canonical length: 435 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

435 residues, UniProt reviewed canonical sequence.

>Q8IV13|CCNJL
     1  MMDEPWWEGR VASDVHCTLR EKELKLPTFR AHSPLLKSRR FFVDILTLLS SHCQLCPAAR
    61  HLAVYLLDHF MDRYNVTTSK QLYTVAVSCL LLANGVSLLS PRLKCSGMIS AHCNLHLPGS
   121  SNSPASAPHP PPTPPQVAET TGKFEDREDH VPKLEQINST RILSSQNFTL TKKELLSTEL
   181  LLLEAFSWNL CLPTPAHFLD YYLLASVSQK DHHCHTWPTT CPRKTKECLK EYAHYFLEVT
   241  LQDHIFYKFQ PSVVAAACVG ASRICLQLSP YWTRDLQRIS SYSLEHLSTC IEILLVVYDN
   301  VLKDAVAVKS QALAMVPGTP PTPTQVLFQP PAYPALGQPA TTLAQFQTPV QDLCLAYRDS
   361  LQAHRSGSLL SGSTGSSLHT PYQPLQPLDM CPVPVPASLS MHMAIAAEPR HCLATTYGSS
   421  YFSGSHMFPT GCFDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNJL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 16 nTPM
testis: 7.6 nTPM
colon: 5.7 nTPM
rectum: 5.2 nTPM
spleen: 4.9 nTPM
lung: 4.7 nTPM

Single-cell type

neutrophils: 375 nCPM
parietal cells: 111 nCPM
renal collecting duct intercalated cells: 102 nCPM
alveolar cells type 2: 86 nCPM
sertoli cells: 78 nCPM
transitional alveolar cells: 71 nCPM

Immune cell

neutrophil: 13 nTPM
NK-cell: 4 nTPM
eosinophil: 0.4 nTPM
basophil: 0.3 nTPM
total PBMC: 0.2 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 39 nTPM
hippocampal formation: 9.5 nTPM
cerebral cortex: 6.2 nTPM
thalamus: 4.5 nTPM
pons: 4.3 nTPM
midbrain: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: 0.32
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

G1/S transition of mitotic cell cycle

Molecular functions

cyclin-dependent protein serine/threonine kinase regulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Cyclin

InteractionsUniProt · HPA

Protein binding partners of CCNJL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KRTAP10-8

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNJL as an antibody target. Whether an autoantibody or antibody against CCNJL could matter depends on whether native CCNJL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNJL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNJL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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