Seroatlas · Human Serome Atlas

SLC23A1

Solute carrier family 23 member 1

Also known as: S23A1_HUMAN, SLC23A2, SVCT1, YSPL3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UHI7
Gene
SLC23A1
Ensembl
ENSG00000170482
Chromosome
5
Canonical length
598 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

598 residues, UniProt reviewed canonical sequence.

>Q9UHI7|SLC23A1
     1  MRAQEDLEGR TQHETTRDPS TPLPTEPKFD MLYKIEDVPP WYLCILLGFQ HYLTCFSGTI
    61  AVPFLLAEAL CVGHDQHMVS QLIGTIFTCV GITTLIQTTV GIRLPLFQAS AFAFLVPAKA
   121  ILALERWKCP PEEEIYGNWS LPLNTSHIWH PRIREVQGAI MVSSVVEVVI GLLGLPGALL
   181  NYIGPLTVTP TVSLIGLSVF QAAGDRAGSH WGISACSILL IILFSQYLRN LTFLLPVYRW
   241  GKGLTLLRIQ IFKMFPIMLA IMTVWLLCYV LTLTDVLPTD PKAYGFQART DARGDIMAIA
   301  PWIRIPYPCQ WGLPTVTAAA VLGMFSATLA GIIESIGDYY ACARLAGAPP PPVHAINRGI
   361  FTEGICCIIA GLLGTGNGST SSSPNIGVLG ITKVGSRRVV QYGAAIMLVL GTIGKFTALF
   421  ASLPDPILGG MFCTLFGMIT AVGLSNLQFV DMNSSRNLFV LGFSMFFGLT LPNYLESNPG
   481  AINTGILEVD QILIVLLTTE MFVGGCLAFI LDNTVPGSPE ERGLIQWKAG AHANSDMSSS
   541  LKSYDFPIGM GIVKRITFLK YIPICPVFKG FSSSSKDQIA IPEDTPENTE TASVCTKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC23A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 62 nTPM
  • fallopian tube: 51 nTPM
  • kidney: 38 nTPM
  • duodenum: 25 nTPM
  • liver: 21 nTPM
  • prostate: 5.9 nTPM

Single-cell type

  • fallopian tube ciliated cells: 43 nCPM
  • endometrial ciliated cells: 34 nCPM
  • enterocytes: 26 nCPM
  • proximal tubule cells: 14 nCPM
  • epicardial cells: 14 nCPM
  • prostatic glandular cells: 12 nCPM

Immune cell

  • plasmacytoid DC: 1.3 nTPM
  • naive B-cell: 0.3 nTPM
  • neutrophil: 0.2 nTPM
  • memory B-cell: 0.1 nTPM
  • T-reg: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • midbrain: 9 nTPM
  • medulla oblongata: 4.4 nTPM
  • cerebellum: 4.3 nTPM
  • white matter: 3.2 nTPM
  • hypothalamus: 2.9 nTPM
  • cerebral cortex: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.02
gnomAD missense Z
1.99
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC23A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC23A1 as an antibody target. Whether an autoantibody or antibody against SLC23A1 could matter depends on whether native SLC23A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC23A1 is annotated at the cell surface, where native SLC23A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC23A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC23A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...