Seroatlas · Human Serome Atlas

GPER1

G-protein coupled estrogen receptor 1

Also known as: CEPR, CMKRL2, DRY12, FEG-1, GPCR-Br, GPER, GPER1_HUMAN, GPR30, LERGU, LERGU2, LyGPR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99527
Gene
GPER1
Ensembl
ENSG00000164850
Chromosome
7
Canonical length
375 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Nucleoli,Vesicles,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q99527|GPER1
     1  MDVTSQARGV GLEMYPGTAQ PAAPNTTSPE LNLSHPLLGT ALANGTGELS EHQQYVIGLF
    61  LSCLYTIFLF PIGFVGNILI LVVNISFREK MTIPDLYFIN LAVADLILVA DSLIEVFNLH
   121  ERYYDIAVLC TFMSLFLQVN MYSSVFFLTW MSFDRYIALA RAMRCSLFRT KHHARLSCGL
   181  IWMASVSATL VPFTAVHLQH TDEACFCFAD VREVQWLEVT LGFIVPFAII GLCYSLIVRV
   241  LVRAHRHRGL RPRRQKALRM ILAVVLVFFV CWLPENVFIS VHLLQRTQPG AAPCKQSFRH
   301  AHPLTGHIVN LAAFSNSCLN PLIYSFLGET FRDKLRLYIE QKTNLPALNR FCHAALKAVI
   361  PDSTEQSDVR FSSAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPER1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 41 nTPM
  • liver: 25 nTPM
  • basal ganglia: 18 nTPM
  • kidney: 15 nTPM
  • cerebral cortex: 13 nTPM
  • amygdala: 12 nTPM

Single-cell type

  • respiratory ionocytes: 36 nCPM
  • tuft cells: 35 nCPM
  • gastric chief cells: 33 nCPM
  • hepatocytes: 28 nCPM
  • kupffer cells: 25 nCPM
  • epicardial cells: 23 nCPM

Immune cell

  • myeloid DC: 5.8 nTPM
  • classical monocyte: 2.9 nTPM
  • intermediate monocyte: 2.7 nTPM
  • total PBMC: 1.3 nTPM
  • non-classical monocyte: 0.8 nTPM
  • memory B-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 17 nTPM
  • amygdala: 16 nTPM
  • thalamus: 14 nTPM
  • basal ganglia: 14 nTPM
  • pons: 12 nTPM
  • midbrain: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0.57
gnomAD missense Z
1.11
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPER1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPER1 as an antibody target. Whether an autoantibody or antibody against GPER1 could matter depends on whether native GPER1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPER1 is annotated at the cell surface, where native GPER1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPER1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPER1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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