Seroatlas · Human Serome Atlas

KCNK3

Potassium channel subfamily K member 3

Also known as: K2p3.1, KCNK3_HUMAN, TASK, TASK-1, TASK1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14649
Gene
KCNK3
Ensembl
ENSG00000171303
Chromosome
2
Canonical length
394 aa
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

394 residues, UniProt reviewed canonical sequence.

>O14649|KCNK3
     1  MKRQNVRTLA LIVCTFTYLL VGAAVFDALE SEPELIERQR LELRQQELRA RYNLSQGGYE
    61  ELERVVLRLK PHKAGVQWRF AGSFYFAITV ITTIGYGHAA PSTDGGKVFC MFYALLGIPL
   121  TLVMFQSLGE RINTLVRYLL HRAKKGLGMR RADVSMANMV LIGFFSCIST LCIGAAAFSH
   181  YEHWTFFQAY YYCFITLTTI GFGDYVALQK DQALQTQPQY VAFSFVYILT GLTVIGAFLN
   241  LVVLRFMTMN AEDEKRDAEH RALLTRNGQA GGGGGGGSAH TTDTASSTAA AGGGGFRNVY
   301  AEVLHFQSMC SCLWYKSREK LQYSIPMIIP RDLSTSDTCV EQSHSSPGGG GRYSDTPSRR
   361  CLCSGAPRSA ISSVSTGLHS LSTFRGLMKR RSSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
169 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 169 nTPM
  • pancreas: 33 nTPM
  • placenta: 23 nTPM
  • lung: 23 nTPM
  • parathyroid gland: 11 nTPM
  • heart muscle: 11 nTPM

Single-cell type

  • adrenal cortex cells: 330 nCPM
  • pancreatic acinar cells: 204 nCPM
  • renal collecting duct principal cells: 93 nCPM
  • pancreatic islet cells: 89 nCPM
  • retinal bipolar cells: 81 nCPM
  • pericytes: 70 nCPM

Immune cell

  • neutrophil: 0.4 nTPM
  • basophil: 0.2 nTPM
  • NK-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • pons: 42 nTPM
  • midbrain: 30 nTPM
  • medulla oblongata: 29 nTPM
  • hypothalamus: 25 nTPM
  • thalamus: 20 nTPM
  • cerebellum: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KCNK3.

Disease | AllUniProt

Conditions KCNK3 is implicated in, by any mechanism.

  • Pulmonary hypertension, primary, 4 (PPH4) MIM:615344

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 287 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.9
gnomAD missense Z
3.55
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCNK3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNK3 as an antibody target. Whether an autoantibody or antibody against KCNK3 could matter depends on whether native KCNK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNK3 is annotated at the cell surface, where native KCNK3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNK3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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