Seroatlas · Human Serome Atlas

KCNK1

Potassium channel subfamily K member 1

Also known as: DPK, K2p1.1, KCNK1_HUMAN, TWIK-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00180
Gene
KCNK1
Ensembl
ENSG00000135750
Chromosome
1
Canonical length
336 aa
Protein class
Predicted membrane proteins, Voltage-gated ion channels
Subcellular location
Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>O00180|KCNK1
     1  MLQSLAGSSC VRLVERHRSA WCFGFLVLGY LLYLVFGAVV FSSVELPYED LLRQELRKLK
    61  RRFLEEHECL SEQQLEQFLG RVLEASNYGV SVLSNASGNW NWDFTSALFF ASTVLSTTGY
   121  GHTVPLSDGG KAFCIIYSVI GIPFTLLFLT AVVQRITVHV TRRPVLYFHI RWGFSKQVVA
   181  IVHAVLLGFV TVSCFFFIPA AVFSVLEDDW NFLESFYFCF ISLSTIGLGD YVPGEGYNQK
   241  FRELYKIGIT CYLLLGLIAM LVVLETFCEL HELKKFRKMF YVKKDKDEDQ VHIIEHDQLS
   301  FSSITDQAAG MKEDQKQNEP FVATQSSACV DGPANH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
109 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 109 nTPM
  • choroid plexus: 70 nTPM
  • heart muscle: 41 nTPM
  • stomach: 36 nTPM
  • epididymis: 29 nTPM
  • cerebral cortex: 29 nTPM

Single-cell type

  • foveolar cells: 553 nCPM
  • endometrial glandular cells: 466 nCPM
  • endometrial secretory cells: 348 nCPM
  • endometrial luminal cells: 338 nCPM
  • ocular epithelial cells: 301 nCPM
  • brain excitatory neurons: 286 nCPM

Immune cell

  • plasmacytoid DC: 6.9 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 116 nTPM
  • choroid plexus: 103 nTPM
  • hippocampal formation: 46 nTPM
  • pons: 46 nTPM
  • cerebral cortex: 43 nTPM
  • medulla oblongata: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0.03
gnomAD missense Z
0.72
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCNK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNK1 as an antibody target. Whether an autoantibody or antibody against KCNK1 could matter depends on whether native KCNK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNK1 is annotated at the cell surface, where native KCNK1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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