Seroatlas · Human Serome Atlas

SERTM2

Serine-rich and transmembrane domain-containing 2

Also known as: LINC00890, SRTM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GWG4
Gene
SERTM2
Ensembl
ENSG00000260802
Chromosome
X
Canonical length
90 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

90 residues, UniProt reviewed canonical sequence.

>A0A1B0GWG4|SERTM2
     1  MMEAHFKYHG NLTGRAHFPT LATEVDTSSD KYSNLYMYVG LFLSLLAILL ILLFTMLLRL
    61  KHVISPINSD STESVPQFTD VEMQSRIPTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERTM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • seminal vesicle: 71 nTPM
  • epididymis: 39 nTPM
  • endometrium: 26 nTPM
  • cervix: 16 nTPM
  • prostate: 9.2 nTPM
  • fallopian tube: 5.8 nTPM

Single-cell type

  • decidual stromal cells: 26 nCPM
  • pituicytes/fscs: 4.8 nCPM
  • fibroblasts: 2.9 nCPM
  • extravillous trophoblasts: 1 nCPM
  • hepatocytes: 1 nCPM
  • hofbauer cells: 1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 1.6 nTPM
  • pons: 0.9 nTPM
  • medulla oblongata: 0.7 nTPM
  • midbrain: 0.6 nTPM
  • thalamus: 0.5 nTPM
  • spinal cord: 0.3 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SERTM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERTM2 as an antibody target. Whether an autoantibody or antibody against SERTM2 could matter depends on whether native SERTM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERTM2 is annotated at the cell surface, where native SERTM2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SERTM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SERTM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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