Seroatlas · Human Serome Atlas

IRF2BP1

Interferon regulatory factor 2-binding protein 1

Also known as: DKFZP434M154, I2BP1_HUMAN, IRF-2BP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IU81
Gene: IRF2BP1
Ensembl: ENSG00000170604
Chromosome: 19
Canonical length: 584 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables transcription corepressor activity and ubiquitin protein ligase activity. Involved in protein polyubiquitination. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

584 residues, UniProt reviewed canonical sequence.

>Q8IU81|IRF2BP1
     1  MASVQASRRQ WCYLCDLPKM PWAMVWDFSE AVCRGCVNFE GADRIELLID AARQLKRSHV
    61  LPEGRSPGPP ALKHPATKDL AAAAAQGPQL PPPQAQPQPS GTGGGVSGQD RYDRATSSGR
   121  LPLPSPALEY TLGSRLANGL GREEAVAEGA RRALLGSMPG LMPPGLLAAA VSGLGSRGLT
   181  LAPGLSPARP LFGSDFEKEK QQRNADCLAE LNEAMRGRAE EWHGRPKAVR EQLLALSACA
   241  PFNVRFKKDH GLVGRVFAFD ATARPPGYEF ELKLFTEYPC GSGNVYAGVL AVARQMFHDA
   301  LREPGKALAS SGFKYLEYER RHGSGEWRQL GELLTDGVRS FREPAPAEAL PQQYPEPAPA
   361  ALCGPPPRAP SRNLAPTPRR RKASPEPEGE AAGKMTTEEQ QQRHWVAPGG PYSAETPGVP
   421  SPIAALKNVA EALGHSPKDP GGGGGPVRAG GASPAASSTA QPPTQHRLVA RNGEAEVSPT
   481  AGAEAVSGGG SGTGATPGAP LCCTLCRERL EDTHFVQCPS VPGHKFCFPC SREFIKAQGP
   541  AGEVYCPSGD KCPLVGSSVP WAFMQGEIAT ILAGDIKVKK ERDP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IRF2BP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 30 nTPM
cerebral cortex: 24 nTPM
skeletal muscle: 21 nTPM
ovary: 21 nTPM
liver: 20 nTPM
pituitary gland: 20 nTPM

Single-cell type

leydig cells: 17 nCPM
breast hormone-responsive cells: 16 nCPM
gastric chief cells: 15 nCPM
fallopian secretory cells: 14 nCPM
breast secretory cells: 14 nCPM
thymic myoid cells: 14 nCPM

Immune cell

naive CD4 T-cell: 0.9 nTPM
gdT-cell: 0.7 nTPM
MAIT T-cell: 0.7 nTPM
memory B-cell: 0.7 nTPM
NK-cell: 0.7 nTPM
memory CD4 T-cell: 0.6 nTPM

Brain region

medulla oblongata: 42 nTPM
white matter: 40 nTPM
cerebral cortex: 39 nTPM
cerebellum: 38 nTPM
midbrain: 36 nTPM
basal ganglia: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 0.99
gnomAD missense Z: 3.34
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IRF2BP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IRF2BP1 as an antibody target. Whether an autoantibody or antibody against IRF2BP1 could matter depends on whether native IRF2BP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IRF2BP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IRF2BP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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