Seroatlas · Human Serome Atlas

ITIH5

Inter-alpha-trypsin inhibitor heavy chain H5

Also known as: ITIH5_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UX2
Gene: ITIH5
Canonical length: 942 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for ITIH5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

942 residues, UniProt reviewed canonical sequence.

>Q86UX2|ITIH5
     1  MLLLLGLCLG LSLCVGSQEE AQSWGHSSEQ DGLRVPRQVR LLQRLKTKPL MTEFSVKSTI
    61  ISRYAFTTVS CRMLNRASED QDIEFQMQIP AAAFITNFTM LIGDKVYQGE ITEREKKSGD
   121  RVKEKRNKTT EENGEKGTEI FRASAVIPSK DKAAFFLSYE ELLQRRLGKY EHSISVRPQQ
   181  LSGRLSVDVN ILESAGIASL EVLPLHNSRQ RGSGRGEDDS GPPPSTVINQ NETFANIIFK
   241  PTVVQQARIA QNGILGDFII RYDVNREQSI GDIQVLNGYF VHYFAPKDLP PLPKNVVFVL
   301  DSSASMVGTK LRQTKDALFT ILHDLRPQDR FSIIGFSNRI KVWKDHLISV TPDSIRDGKV
   361  YIHHMSPTGG TDINGALQRA IRLLNKYVAH SGIGDRSVSL IVFLTDGKPT VGETHTLKIL
   421  NNTREAARGQ VCIFTIGIGN DVDFRLLEKL SLENCGLTRR VHEEEDAGSQ LIGFYDEIRT
   481  PLLSDIRIDY PPSSVVQATK TLFPNYFNGS EIIIAGKLVD RKLDHLHVEV TASNSKKFII
   541  LKTDVPVRPQ KAGKDVTGSP RPGGDGEGDT NHIERLWSYL TTKELLSSWL QSDDEPEKER
   601  LRQRAQALAV SYRFLTPFTS MKLRGPVPRM DGLEEAHGMS AAMGPEPVVQ SVRGAGTQPG
   661  PLLKKPYQPR IKISKTSVDG DPHFVVDFPL SRLTVCFNID GQPGDILRLV SDHRDSGVTV
   721  NGELIGAPAP PNGHKKQRTY LRTITILINK PERSYLEITP SRVILDGGDR LVLPCNQSVV
   781  VGSWGLEVSV SANANVTVTI QGSIAFVILI HLYKKPAPFQ RHHLGFYIAN SEGLSSNCHG
   841  LLGQFLNQDA RLTEDPAGPS QNLTHPLLLQ VGEGPEAVLT VKGHQVPVVW KQRKIYNGEE
   901  QIDCWFARNN AAKLIDGEYK DYLAFHPFDT GMTLGQGMSR EL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITIH5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 106 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 106 nTPM
placenta: 82 nTPM
colon: 59 nTPM
blood vessel: 59 nTPM
urinary bladder: 53 nTPM
breast: 51 nTPM

Single-cell type

adipocytes: 524 nCPM
cytotrophoblasts: 478 nCPM
salivary ionocytes: 319 nCPM
podocytes: 311 nCPM
syncytiotrophoblasts: 300 nCPM
fibro-adipogenic progenitors: 290 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 45 nTPM
thalamus: 32 nTPM
pons: 26 nTPM
cerebellum: 25 nTPM
medulla oblongata: 23 nTPM
basal ganglia: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 0.14

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

hyaluronan metabolic process

Molecular functions

serine-type endopeptidase inhibitor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITIH5 as an antibody target. Whether an autoantibody or antibody against ITIH5 could matter depends on whether native ITIH5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITIH5 is annotated as secreted, so native ITIH5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ITIH5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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