Inter-alpha-trypsin inhibitor heavy chain
IPR050934
Definition
The ITIH family proteins are involved in various biological processes, primarily acting as carriers or binding proteins for hyaluronan in serum. They play a crucial role in regulating the localization, synthesis, and degradation of hyaluronan, which is essential for cells during biological processes. Some members of the family are known to function as type II acute-phase proteins (APPs) that respond to inflammatory trauma and may contribute to liver development or regeneration. Additionally, certain ITIH family members have been implicated in tumor suppression, suggesting a potential role in cancer biology.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...