Vault protein inter-alpha-trypsin domain

Definition

Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains. ITIs play a role in extracellular matrix (ECM) stabilisation and tumour metastasis as well as in plasma protease inhibition PMID:14744536. The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain ([pfam:PF00092]) in ITI heavy chains (ITIHs) and their precursors.

8 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (8 proteins: gene, accession, name)

• ITIH1
• ITIH2
• ITIH3
• ITIH4
• ITIH5
• ITIH6
• PARP4
• VWA5A