Inter-alpha-trypsin inhibitor heavy chain, C-terminal

Definition

This entry represents the C-terminal region of inter-alpha-trypsin inhibitor heavy chains. Inter-alpha-trypsin inhibitors are glycoproteins with a high inhibitory activity against trypsin, built up from different combinations of four polypeptides: bikunin and the three heavy chains that belong to this family (HC1, HC2, HC3). The heavy chains do not have any protease inhibitory properties but have the capacity to interactin vitroandin vivowith hyaluronic acid, which promotes the stability of the extra-cellular matrix. This domain is associated with the VWA domain [interpro:IPR002035].

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• ITIH1
• ITIH2
• ITIH3
• ITIH4
• ITIH5
• ITIH6