Type I cytokine receptor, cytokine-binding domain

Definition

The alpha chain of the interleukin-6 receptor (IL-6R-alpha) consists of a signal peptide, an extracellular region, a transmembrane domain, and a short cytoplasmic domain. The extracellular region is highly modular, consisting of three domains (D1, D2, and D3). The N-terminal domain D1 is characteristic of the Ig superfamily, and domains D2 and D3 are homologous to cytokine-binding domains (CBD) consisting of two fibronectin type III (FnIII) domains [[cite:PMID:2169613], [cite:PMID:12461182]]. This domain corresponds to the D2 domain in IL-6R-alpha and is also found in other members of the type I cytokine receptor family.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• CSF2RA
• IL13RA1
• IL13RA2
• IL31RA
• IL3RA
• IL5RA
• IL6R