Seroatlas · Human Serome Atlas

IL23R

Interleukin-23 receptor

Also known as: IL-23R, IL23R_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VWK5
Gene
IL23R
Ensembl
ENSG00000162594
Chromosome
1
Canonical length
629 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

629 residues, UniProt reviewed canonical sequence.

>Q5VWK5|IL23R
     1  MNQVTIQWDA VIALYILFSW CHGGITNINC SGHIWVEPAT IFKMGMNISI YCQAAIKNCQ
    61  PRKLHFYKNG IKERFQITRI NKTTARLWYK NFLEPHASMY CTAECPKHFQ ETLICGKDIS
   121  SGYPPDIPDE VTCVIYEYSG NMTCTWNAGK LTYIDTKYVV HVKSLETEEE QQYLTSSYIN
   181  ISTDSLQGGK KYLVWVQAAN ALGMEESKQL QIHLDDIVIP SAAVISRAET INATVPKTII
   241  YWDSQTTIEK VSCEMRYKAT TNQTWNVKEF DTNFTYVQQS EFYLEPNIKY VFQVRCQETG
   301  KRYWQPWSSL FFHKTPETVP QVTSKAFQHD TWNSGLTVAS ISTGHLTSDN RGDIGLLLGM
   361  IVFAVMLSIL SLIGIFNRSF RTGIKRRILL LIPKWLYEDI PNMKNSNVVK MLQENSELMN
   421  NNSSEQVLYV DPMITEIKEI FIPEHKPTDY KKENTGPLET RDYPQNSLFD NTTVVYIPDL
   481  NTGYKPQISN FLPEGSHLSN NNEITSLTLK PPVDSLDSGN NPRLQKHPNF AFSVSSVNSL
   541  SNTIFLGELS LILNQGECSS PDIQNSVEEE TTMLLENDSP SETIPEQTLL PDEFVSCLGI
   601  VNEELPSINT YFPQNILESH FNRISLLEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL23R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
2.2 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 2.2 nTPM
  • testis: 1.1 nTPM
  • colon: 1 nTPM
  • rectum: 1 nTPM
  • tonsil: 0.5 nTPM
  • appendix: 0.4 nTPM

Single-cell type

  • innate lymphoid cells: 143 nCPM
  • sertoli cells: 22 nCPM
  • late primary spermatocytes: 18 nCPM
  • adrenal cortex cells: 17 nCPM
  • t-cells: 15 nCPM
  • early spermatids: 12 nCPM

Immune cell

  • MAIT T-cell: 24 nTPM
  • memory CD8 T-cell: 2.6 nTPM
  • gdT-cell: 2.1 nTPM
  • NK-cell: 0.8 nTPM
  • memory CD4 T-cell: 0.7 nTPM
  • T-reg: 0.6 nTPM

Brain region

  • midbrain: 0.7 nTPM
  • cerebellum: 0.5 nTPM
  • cerebral cortex: 0.5 nTPM
  • choroid plexus: 0.5 nTPM
  • hippocampal formation: 0.5 nTPM
  • hypothalamus: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL23R.

Disease | AllUniProt

Conditions IL23R is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0
gnomAD missense Z
1.08
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL23R in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL23R as an antibody target. Whether an autoantibody or antibody against IL23R could matter depends on whether native IL23R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL23R is annotated at the cell surface, where native IL23R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IL23R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL23R. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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