IL13RA2

Protein identityUniProt · HPA

UniProt accession

Q14627

Gene

IL13RA2

Ensembl

ENSG00000123496

Chromosome

X

Canonical length

380 aa

Protein class

Cancer-related genes, CD markers, Predicted membrane proteins

Subcellular location

Nucleoplasm,Vesicles,Plasma membrane,Cell Junctions

OverviewNCBI Gene

The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

380 residues, UniProt reviewed canonical sequence.

>Q14627|IL13RA2
     1  MAFVCLAIGC LYTFLISTTF GCTSSSDTEI KVNPPQDFEI VDPGYLGYLY LQWQPPLSLD
    61  HFKECTVEYE LKYRNIGSET WKTIITKNLH YKDGFDLNKG IEAKIHTLLP WQCTNGSEVQ
   121  SSWAETTYWI SPQGIPETKV QDMDCVYYNW QYLLCSWKPG IGVLLDTNYN LFYWYEGLDH
   181  ALQCVDYIKA DGQNIGCRFP YLEASDYKDF YICVNGSSEN KPIRSSYFTF QLQNIVKPLP
   241  PVYLTFTRES SCEIKLKWSI PLGPIPARCF DYEIEIREDD TTLVTATVEN ETYTLKTTNE
   301  TRQLCFVVRS KVNIYCSDDG IWSEWSDKQC WEGEDLSKKT LLRFWLPFGF ILILVIFVTG
   361  LLLRKPNTYP KMIPEFFCDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL13RA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

31 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL13RA2.

Disease | ImmuneIEDB

Conditions an epitope on IL13RA2 was assayed in.

• glioblastoma T cell
• brain glioblastoma multiforme T cell
• anaplastic astrocytoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.18

gnomAD pLI

0

gnomAD missense Z

0.76

DepMap mean gene effect

0.07

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cytokine-mediated signaling pathway
• immunoglobulin mediated immune response
• interleukin-13-mediated signaling pathway
• negative regulation of immunoglobulin production
• negative regulation of mast cell degranulation
• positive regulation of cell population proliferation

Molecular functions

• cytokine binding
• cytokine receptor activity

Cellular components

• external side of plasma membrane
• extracellular region
• extracellular space
• plasma membrane
• receptor complex

Protein domainsUniProt · Pfam · InterPro

• Short hematopoietin receptor, family 2, conserved site
• Fibronectin type III
• Immunoglobulin-like fold
• Type I cytokine receptor, cytokine-binding domain
• Fibronectin type III superfamily
• Interleukin-6 receptor alpha chain, binding

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Glycoprotein
• Membrane
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of IL13RA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IL4RA
• IL13
• IL4R