Seroatlas · Human Serome Atlas

IL11RA

Interleukin-11 receptor subunit alpha

Also known as: I11RA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14626
Gene
IL11RA
Ensembl
ENSG00000137070
Chromosome
9
Canonical length
422 aa
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Vesicles,Plasma membrane
Secretome location
Secreted to blood

OverviewNCBI Gene

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>Q14626|IL11RA
     1  MSSSCSGLSR VLVAVATALV SASSPCPQAW GPPGVQYGQP GRSVKLCCPG VTAGDPVSWF
    61  RDGEPKLLQG PDSGLGHELV LAQADSTDEG TYICQTLDGA LGGTVTLQLG YPPARPVVSC
   121  QAADYENFSC TWSPSQISGL PTRYLTSYRK KTVLGADSQR RSPSTGPWPC PQDPLGAARC
   181  VVHGAEFWSQ YRINVTEVNP LGASTRLLDV SLQSILRPDP PQGLRVESVP GYPRRLRASW
   241  TYPASWPCQP HFLLKFRLQY RPAQHPAWST VEPAGLEEVI TDAVAGLPHA VRVSARDFLD
   301  AGTWSTWSPE AWGTPSTGTI PKEIPAWGQL HTQPEVEPQV DSPAPPRPSL QPHPRLLDHR
   361  DSVEQVAVLA SLGILSFLGL VAGALALGLW LRLRRGGKDG SPKPGFLASV IPVDRRPGAP
   421  NL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL11RA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 36 nTPM
  • tongue: 24 nTPM
  • blood vessel: 23 nTPM
  • skin: 15 nTPM
  • skeletal muscle: 13 nTPM
  • ovary: 12 nTPM

Single-cell type

  • astrocytes: 25 nCPM
  • bergmann glia: 23 nCPM
  • proximal tubule cells: 17 nCPM
  • podocytes: 15 nCPM
  • brain inhibitory neurons: 14 nCPM
  • renal connecting tubule cells: 11 nCPM

Immune cell

  • basophil: 2 nTPM
  • memory CD4 T-cell: 2 nTPM
  • MAIT T-cell: 1.7 nTPM
  • naive CD4 T-cell: 1.6 nTPM
  • total PBMC: 1.5 nTPM
  • naive CD8 T-cell: 1.4 nTPM

Brain region

  • white matter: 8.4 nTPM
  • medulla oblongata: 7.7 nTPM
  • basal ganglia: 7.6 nTPM
  • thalamus: 7.5 nTPM
  • midbrain: 7.3 nTPM
  • spinal cord: 7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL11RA.

Disease | AllUniProt

Conditions IL11RA is implicated in, by any mechanism.

  • Craniosynostosis and dental anomalies (CRSDA) MIM:614188

Disease | GeneticClinVar

23 pathogenic / likely-pathogenic of 129 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.54
gnomAD pLI
0
gnomAD missense Z
0.64
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL11RA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL11RA as an antibody target. Whether an autoantibody or antibody against IL11RA could matter depends on whether native IL11RA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL11RA is annotated as secreted, so native IL11RA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL11RA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL11RA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...