Seroatlas · Human Serome Atlas

MEI4

Meiosis-specific protein MEI4

Also known as: MEI4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MW99
Gene: MEI4
Ensembl: ENSG00000269964
Chromosome: 6
Canonical length: 385 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in meiosis I cell cycle process; oogenesis; and spermatogenesis. Predicted to be located in chromosome. Predicted to be active in lateral element. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>A8MW99|MEI4
     1  MDVQKWYLRT SKLALALAII RSKPADKSSR EYTEHLAMLL SEEQSKWRSK VEILEAEVMQ
    61  LRQKLLVSRL CSGSFKSGYV SSQLEAQEPK SSESTLTSME DSGCDLSNEQ RTESSDLSQH
   121  FVESCTPTHF PPLPLVKRPC AILQNPLSSH MQFLQYLLEL KNLTESGNLK RDLTHFEKDS
   181  STVSDSVFQL LDGLITFYRN PKLPFSRFWT EAVGTLASLI SDYNLSSHIL KKCSKKLEEF
   241  EKTLLHAILG NNHINQFQVQ HYVSQSLVTL GNCSLLRKSI ISLLLSEVNG FADDLGAINQ
   301  EQASYDVSRY ENIFYLFWVL EQLLQKETEE GNTSSIGHDD QEIKKFLQKH DETIFQLSDA
   361  FPLFTFYLWR VGILLSSAQI ETLRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEI4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

kidney: 3.9 nTPM
testis: 3.2 nTPM
thyroid gland: 2 nTPM
pancreas: 1.9 nTPM
liver: 0.8 nTPM
adrenal gland: 0.6 nTPM

Single-cell type

late primary spermatocytes: 108 nCPM
sertoli cells: 85 nCPM
gonadotrophs: 78 nCPM
early spermatids: 76 nCPM
proximal tubule cells: 69 nCPM
somatotrophs: 61 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 2.6 nTPM
medulla oblongata: 1.6 nTPM
hypothalamus: 1.4 nTPM
white matter: 1.4 nTPM
spinal cord: 1.2 nTPM
midbrain: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: 0.07
DepMap dependency class: selective

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Meiosis-specific protein MEI4
Meiosis-specific protein Mei4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MEI4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

IHO1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEI4 as an antibody target. Whether an autoantibody or antibody against MEI4 could matter depends on whether native MEI4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEI4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEI4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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