Seroatlas · Human Serome Atlas

IGSF8

Immunoglobulin superfamily member 8

Also known as: CD316, CD81P3, EWI2, IGSF8_HUMAN, PGRL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969P0
Gene
IGSF8
Ensembl
ENSG00000162729
Chromosome
1
Canonical length
613 aa
Protein class
CD markers, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

613 residues, UniProt reviewed canonical sequence.

>Q969P0|IGSF8
     1  MGALRPTLLP PSLPLLLLLM LGMGCWAREV LVPEGPLYRV AGTAVSISCN VTGYEGPAQQ
    61  NFEWFLYRPE APDTALGIVS TKDTQFSYAV FKSRVVAGEV QVQRLQGDAV VLKIARLQAQ
   121  DAGIYECHTP STDTRYLGSY SGKVELRVLP DVLQVSAAPP GPRGRQAPTS PPRMTVHEGQ
   181  ELALGCLART STQKHTHLAV SFGRSVPEAP VGRSTLQEVV GIRSDLAVEA GAPYAERLAA
   241  GELRLGKEGT DRYRMVVGGA QAGDAGTYHC TAAEWIQDPD GSWAQIAEKR AVLAHVDVQT
   301  LSSQLAVTVG PGERRIGPGE PLELLCNVSG ALPPAGRHAA YSVGWEMAPA GAPGPGRLVA
   361  QLDTEGVGSL GPGYEGRHIA MEKVASRTYR LRLEAARPGD AGTYRCLAKA YVRGSGTRLR
   421  EAASARSRPL PVHVREEGVV LEAVAWLAGG TVYRGETASL LCNISVRGGP PGLRLAASWW
   481  VERPEDGELS SVPAQLVGGV GQDGVAELGV RPGGGPVSVE LVGPRSHRLR LHSLGPEDEG
   541  VYHCAPSAWV QHADYSWYQA GSARSGPVTV YPYMHALDTL FVPLLVGTGV ALVTGATVLG
   601  TITCCFMKRL RKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGSF8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
154 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 154 nTPM
  • cerebellum: 137 nTPM
  • cerebral cortex: 134 nTPM
  • hippocampal formation: 109 nTPM
  • basal ganglia: 95 nTPM
  • midbrain: 86 nTPM

Single-cell type

  • extravillous trophoblasts: 308 nCPM
  • oligodendrocytes: 127 nCPM
  • müller glia: 93 nCPM
  • syncytiotrophoblasts: 86 nCPM
  • epididymal principal cells: 78 nCPM
  • brain excitatory neurons: 63 nCPM

Immune cell

  • T-reg: 27 nTPM
  • naive CD8 T-cell: 26 nTPM
  • memory CD8 T-cell: 26 nTPM
  • naive CD4 T-cell: 24 nTPM
  • naive B-cell: 23 nTPM
  • gdT-cell: 22 nTPM

Brain region

  • white matter: 261 nTPM
  • cerebral cortex: 194 nTPM
  • medulla oblongata: 177 nTPM
  • basal ganglia: 171 nTPM
  • pons: 155 nTPM
  • spinal cord: 154 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.05
gnomAD pLI
0
gnomAD missense Z
0.44
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IGSF8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGSF8 as an antibody target. Whether an autoantibody or antibody against IGSF8 could matter depends on whether native IGSF8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGSF8 is annotated at the cell surface, where native IGSF8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGSF8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGSF8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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