Seroatlas · Human Serome Atlas

PPP2R2B

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

Also known as: 2ABB_HUMAN, B55beta, PR52B, PR55-BETA, SCA12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q00005
Gene
PPP2R2B
Ensembl
ENSG00000156475
Chromosome
5
Canonical length
443 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 55-78 copies in cases of SCA12. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

443 residues, UniProt reviewed canonical sequence.

>Q00005|PPP2R2B
     1  MEEDIDTRKI NNSFLRDHSY ATEADIISTV EFNHTGELLA TGDKGGRVVI FQREQESKNQ
    61  VHRRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPQ QNAAYFLLST NDKTVKLWKV
   121  SERDKRPEGY NLKDEEGRLR DPATITTLRV PVLRPMDLMV EATPRRVFAN AHTYHINSIS
   181  VNSDYETYMS ADDLRINLWN FEITNQSFNI VDIKPANMEE LTEVITAAEF HPHHCNTFVY
   241  SSSKGTIRLC DMRASALCDR HTKFFEEPED PSNRSFFSEI ISSISDVKFS HSGRYIMTRD
   301  YLTVKVWDLN MENRPIETYQ VHDYLRSKLC SLYENDCIFD KFECVWNGSD SVIMTGSYNN
   361  FFRMFDRNTK RDVTLEASRE NSKPRAILKP RKVCVGGKRR KDEISVDSLD FSKKILHTAW
   421  HPSENIIAVA ATNNLYIFQD KVN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP2R2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
60 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 60 nTPM
  • cerebral cortex: 60 nTPM
  • amygdala: 58 nTPM
  • midbrain: 55 nTPM
  • hippocampal formation: 50 nTPM
  • spinal cord: 44 nTPM

Single-cell type

  • oligodendrocytes: 6,650 nCPM
  • bergmann glia: 4,881 nCPM
  • pituitary stem cells: 3,199 nCPM
  • astrocytes: 2,900 nCPM
  • rod photoreceptor cells: 1,821 nCPM
  • late spermatids: 1,600 nCPM

Immune cell

  • memory CD8 T-cell: 6.2 nTPM
  • gdT-cell: 5.2 nTPM
  • MAIT T-cell: 4.1 nTPM
  • naive CD8 T-cell: 3.8 nTPM
  • T-reg: 3.4 nTPM
  • NK-cell: 2.9 nTPM

Brain region

  • white matter: 157 nTPM
  • thalamus: 153 nTPM
  • basal ganglia: 151 nTPM
  • cerebral cortex: 131 nTPM
  • hippocampal formation: 125 nTPM
  • midbrain: 123 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PPP2R2B.

Disease | AllUniProt

Conditions PPP2R2B is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.98
gnomAD missense Z
2.25
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP2R2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP2R2B as an antibody target. Whether an autoantibody or antibody against PPP2R2B could matter depends on whether native PPP2R2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP2R2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP2R2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPP2R2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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