Cell Adhesion and Cytoskeletal Organization
IPR050958
Definition
The protein family is involved in various cellular processes including cell adhesion, migration, cytoskeletal organization, and neural development. Members function in actin dynamics, serving as scaffolding molecules that influence actin polymerization and the assembly of actin filaments. They play roles in establishing cell morphology, motility, and interactions with the extracellular matrix. Some members are integral components of basement membranes, contributing to barrier selectivity and vascularization. Others mediate cellular responses to guidance cues in neuronal development and are involved in the Wnt signaling pathway. The family includes proteins that regulate synapse formation and maintenance, as well as those that participate in the architecture of epithelial cell junctions and myocardial remodeling.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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