Seroatlas · Human Serome Atlas

FANCF

Fanconi anemia group F protein

Also known as: FAF, FANCF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NPI8
Gene
FANCF
Ensembl
ENSG00000183161
Chromosome
11
Canonical length
374 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>Q9NPI8|FANCF
     1  MESLLQHLDR FSELLAVSST TYVSTWDPAT VRRALQWARY LRHIHRRFGR HGPIRTALER
    61  RLHNQWRQEG GFGRGPVPGL ANFQALGHCD VLLSLRLLEN RALGDAARYH LVQQLFPGPG
   121  VRDADEETLQ ESLARLARRR SAVHMLRFNG YRENPNLQED SLMKTQAELL LERLQEVGKA
   181  EAERPARFLS SLWERLPQNN FLKVIAVALL QPPLSRRPQE ELEPGIHKSP GEGSQVLVHW
   241  LLGNSEVFAA FCRALPAGLL TLVTSRHPAL SPVYLGLLTD WGQRLHYDLQ KGIWVGTESQ
   301  DVPWEELHNR FQSLCQAPPP LKDKVLTALE TCKAQDGDFE VPGLSIWTDL LLALRSGAFR
   361  KRQVLGLSAG LSSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FANCF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
8.8 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 8.8 nTPM
  • thymus: 8.7 nTPM
  • fallopian tube: 8.3 nTPM
  • epididymis: 8.1 nTPM
  • lymph node: 7.7 nTPM
  • duodenum: 7.4 nTPM

Single-cell type

  • early spermatids: 173 nCPM
  • late primary spermatocytes: 113 nCPM
  • respiratory ciliated cells: 37 nCPM
  • cardiomyocytes: 31 nCPM
  • fallopian tube ciliated cells: 31 nCPM
  • parietal cells: 28 nCPM

Immune cell

  • naive B-cell: 21 nTPM
  • naive CD4 T-cell: 19 nTPM
  • MAIT T-cell: 18 nTPM
  • eosinophil: 17 nTPM
  • naive CD8 T-cell: 16 nTPM
  • memory B-cell: 16 nTPM

Brain region

  • choroid plexus: 11 nTPM
  • thalamus: 8 nTPM
  • white matter: 7.4 nTPM
  • midbrain: 7.3 nTPM
  • medulla oblongata: 7.2 nTPM
  • spinal cord: 7.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FANCF.

Disease | AllUniProt

Conditions FANCF is implicated in, by any mechanism.

  • Fanconi anemia complementation group F (FANCF) MIM:603467

Disease | GeneticClinVar

57 pathogenic / likely-pathogenic of 540 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Fanconi anemia complementation group F
  • Fanconi anemia
  • FANCF-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.53
gnomAD pLI
0.46
gnomAD missense Z
-1.83
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Fanconi anemia group F protein
  • FANCF, C-terminal domain superfamily
  • Fanconi anemia group F protein (FANCF)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FANCF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FANCF as an antibody target. Whether an autoantibody or antibody against FANCF could matter depends on whether native FANCF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FANCF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FANCF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FANCF. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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