HS1BP3
HCLS1-binding protein 3
Also known as: FLJ14249, H1BP3_HUMAN, HS1-BP3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q53T59
- Gene
- HS1BP3
- Ensembl
- ENSG00000118960
- Chromosome
- 2
- Canonical length
- 392 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoli,Cytosol
OverviewNCBI Gene
The protein encoded by this gene shares similarity with mouse Hs1bp3, an Hcls1/Hs1-interacting protein that may be involved in lymphocyte activation. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
392 residues, UniProt reviewed canonical sequence.
>Q53T59|HS1BP3
1 MQSPAVLVTS RRLQNAHTGL DLTVPQHQEV RGKMMSGHVE YQILVVTRLA AFKSAKHRPE
61 DVVQFLVSKK YSEIEEFYQK LSSRYAAASL PPLPRKVLFV GESDIRERRA VFNEILRCVS
121 KDAELAGSPE LLEFLGTRSP GAAGLTSRDS SVLDGTDSQT GNDEEAFDFF EEQDQVAEEG
181 PPVQSLKGED AEESLEEEEA LDPLGIMRSK KPKKHPKVAV KAKPSPRLTI FDEEVDPDEG
241 LFGPGRKLSP QDPSEDVSSV DPLKLFDDPD LGGAIPLGDS LLLPAACESG GPTPSLSHRD
301 ASKELFRVEE DLDQILNLGA EPKPKPQLKP KPPVAAKPVI PRKPAVPPKA GPAEAVAGQQ
361 KPQEQIQAMD EMDILQYIQD HDTPAQAAPS LFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HS1BP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 54 nTPM
Expression across tissuesHPA
Tissue
- liver: 54 nTPM
- blood vessel: 33 nTPM
- colon: 32 nTPM
- urinary bladder: 30 nTPM
- adrenal gland: 29 nTPM
- prostate: 25 nTPM
Single-cell type
- late spermatids: 73 nCPM
- hofbauer cells: 52 nCPM
- retinal horizontal cells: 46 nCPM
- proximal tubule cells: 38 nCPM
- early spermatids: 35 nCPM
- kupffer cells: 35 nCPM
Immune cell
- non-classical monocyte: 18 nTPM
- basophil: 18 nTPM
- neutrophil: 18 nTPM
- classical monocyte: 15 nTPM
- eosinophil: 15 nTPM
- intermediate monocyte: 14 nTPM
Brain region
- white matter: 39 nTPM
- thalamus: 36 nTPM
- medulla oblongata: 34 nTPM
- basal ganglia: 34 nTPM
- choroid plexus: 32 nTPM
- midbrain: 32 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.22
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.19
- DepMap mean gene effect
- -0.11
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Phox homology
- PX domain superfamily
- PX domain
- HCLS1-binding protein 3, PX domain
- HCLS1-binding protein 3
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of HS1BP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HS1BP3 as an antibody target. Whether an autoantibody or antibody against HS1BP3 could matter depends on whether native HS1BP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HS1BP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HS1BP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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