Seroatlas · Human Serome Atlas

GULP1

PTB domain-containing engulfment adapter protein 1

Also known as: CED-6, CED6, GULP, GULP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBP9
Gene: GULP1
Ensembl: ENSG00000144366
Chromosome: 2
Canonical length: 304 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>Q9UBP9|GULP1
     1  MNRAFSRKKD KTWMHTPEAL SKHFIPYNAK FLGSTEVEQP KGTEVVRDAV RKLKFARHIK
    61  KSEGQKIPKV ELQISIYGVK ILEPKTKEVQ HNCQLHRISF CADDKTDKRI FTFICKDSES
   121  NKHLCYVFDS EKCAEEITLT IGQAFDLAYR KFLESGGKDV ETRKQIAGLQ KRIQDLETEN
   181  MELKNKVQDL ENQLRITQVS APPAGSMTPK SPSTDIFDMI PFSPISHQSS MPTRNGTQPP
   241  PVPSRSTEIK RDLFGAEPFD PFNCGAADFP PDIQSKLDEM QEGFKMGLTL EGTVFCLDPL
   301  DSRC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GULP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 78 nTPM

Expression across tissuesHPA

Tissue

epididymis: 78 nTPM
endometrium: 32 nTPM
blood vessel: 30 nTPM
prostate: 25 nTPM
cervix: 25 nTPM
seminal vesicle: 25 nTPM

Single-cell type

choroid plexus epithelial cells: 1,426 nCPM
syncytiotrophoblasts: 861 nCPM
podocytes: 820 nCPM
retinal pigment epithelial cells: 810 nCPM
pancreatic acinar cells: 480 nCPM
renal collecting duct intercalated cells: 400 nCPM

Immune cell

basophil: 0.2 nTPM
classical monocyte: 0.2 nTPM
neutrophil: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
eosinophil: 0 nTPM

Brain region

choroid plexus: 80 nTPM
pons: 47 nTPM
hypothalamus: 24 nTPM
medulla oblongata: 21 nTPM
basal ganglia: 21 nTPM
midbrain: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.69
gnomAD missense Z: 0.98
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GULP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GULP1 as an antibody target. Whether an autoantibody or antibody against GULP1 could matter depends on whether native GULP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GULP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GULP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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