Seroatlas · Human Serome Atlas

DEDD2

DNA-binding death effector domain-containing protein 2

Also known as: DEDD2_HUMAN, FLAME-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXF8
Gene: DEDD2
Ensembl: ENSG00000160570
Chromosome: 19
Canonical length: 326 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>Q8WXF8|DEDD2
     1  MALSGSTPAP CWEEDECLDY YGMLSLHRMF EVVGGQLTEC ELELLAFLLD EAPGAAGGLA
    61  RARSGLELLL ELERRGQCDE SNLRLLGQLL RVLARHDLLP HLARKRRRPV SPERYSYGTS
   121  SSSKRTEGSC RRRRQSSSSA NSQQGQWETG SPPTKRQRRS RGRPSGGARR RRRGAPAAPQ
   181  QQSEPARPSS EGKVTCDIRL RVRAEYCEHG PALEQGVASR RPQALARQLD VFGQATAVLR
   241  SRDLGSVVCD IKFSELSYLD AFWGDYLSGA LLQALRGVFL TEALREAVGR EAVRLLVSVD
   301  EADYEAGRRR LLLMEEEGGR RPTEAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DEDD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 22 nTPM
pituitary gland: 20 nTPM
spleen: 19 nTPM
cerebral cortex: 17 nTPM
hypothalamus: 16 nTPM
lung: 14 nTPM

Single-cell type

syncytiotrophoblasts: 211 nCPM
neutrophils: 174 nCPM
esophageal apical cells: 111 nCPM
epididymal efferent duct absorptive cells: 75 nCPM
colonocytes: 71 nCPM
epididymal principal cells: 68 nCPM

Immune cell

neutrophil: 127 nTPM
eosinophil: 95 nTPM
non-classical monocyte: 83 nTPM
basophil: 82 nTPM
intermediate monocyte: 73 nTPM
total PBMC: 72 nTPM

Brain region

hypothalamus: 44 nTPM
cerebral cortex: 42 nTPM
white matter: 42 nTPM
pons: 39 nTPM
thalamus: 32 nTPM
midbrain: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.06
gnomAD missense Z: 1.34
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DEDD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DEDD2 as an antibody target. Whether an autoantibody or antibody against DEDD2 could matter depends on whether native DEDD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DEDD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DEDD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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