GRIN2C

Protein identityUniProt · HPA

UniProt accession

Q14957

Gene

GRIN2C

Ensembl

ENSG00000161509

Chromosome

17

Canonical length

1233 aa

Protein class

FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

1233 residues, UniProt reviewed canonical sequence.

>Q14957|GRIN2C
     1  MGGALGPALL LTSLFGAWAG LGPGQGEQGM TVAVVFSSSG PPQAQFRARL TPQSFLDLPL
    61  EIQPLTVGVN TTNPSSLLTQ ICGLLGAAHV HGIVFEDNVD TEAVAQILDF ISSQTHVPIL
   121  SISGGSAVVL TPKEPGSAFL QLGVSLEQQL QVLFKVLEEY DWSAFAVITS LHPGHALFLE
   181  GVRAVADASH VSWRLLDVVT LELGPGGPRA RTQRLLRQLD APVFVAYCSR EEAEVLFAEA
   241  AQAGLVGPGH VWLVPNLALG STDAPPATFP VGLISVVTES WRLSLRQKVR DGVAILALGA
   301  HSYWRQHGTL PAPAGDCRVH PGPVSPAREA FYRHLLNVTW EGRDFSFSPG GYLVQPTMVV
   361  IALNRHRLWE MVGRWEHGVL YMKYPVWPRY SASLQPVVDS RHLTVATLEE RPFVIVESPD
   421  PGTGGCVPNT VPCRRQSNHT FSSGDVAPYT KLCCKGFCID ILKKLARVVK FSYDLYLVTN
   481  GKHGKRVRGV WNGMIGEVYY KRADMAIGSL TINEERSEIV DFSVPFVETG ISVMVARSNG
   541  TVSPSAFLEP YSPAVWVMMF VMCLTVVAIT VFMFEYFSPV SYNQNLTRGK KSGGPAFTIG
   601  KSVWLLWALV FNNSVPIENP RGTTSKIMVL VWAFFAVIFL ASYTANLAAF MIQEQYIDTV
   661  SGLSDKKFQR PQDQYPPFRF GTVPNGSTER NIRSNYRDMH THMVKFNQRS VEDALTSLKM
   721  GKLDAFIYDA AVLNYMAGKD EGCKLVTIGS GKVFATTGYG IAMQKDSHWK RAIDLALLQF
   781  LGDGETQKLE TVWLSGICQN EKNEVMSSKL DIDNMAGVFY MLLVAMGLAL LVFAWEHLVY
   841  WKLRHSVPNS SQLDFLLAFS RGIYSCFSGV QSLASPPRQA SPDLTASSAQ ASVLKMLQAA
   901  RDMVTTAGVS SSLDRATRTI ENWGGGRRAP PPSPCPTPRS GPSPCLPTPD PPPEPSPTGW
   961  GPPDGGRAAL VRRAPQPPGR PPTPGPPLSD VSRVSRRPAW EARWPVRTGH CGRHLSASER
  1021  PLSPARCHYS SFPRADRSGR PFLPLFPELE DLPLLGPEQL ARREALLHAA WARGSRPRHA
  1081  SLPSSVAEAF ARPSSLPAGC TGPACARPDG HSACRRLAQA QSMCLPIYRE ACQEGEQAGA
  1141  PAWQHRQHVC LHAHAHLPFC WGAVCPHLPP CASHGSWLSG AWGPLGHRGR TLGLGTGYRD
  1201  SGGLDEISRV ARGTQGFPGP CTWRRISSLE SEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRIN2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

3

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

114 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.72

gnomAD pLI

0

gnomAD missense Z

1.61

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• brain development
• calcium ion transmembrane import into cytosol
• directional locomotion
• excitatory chemical synaptic transmission
• excitatory postsynaptic potential
• glutamate receptor signaling pathway
• ionotropic glutamate receptor signaling pathway
• long-term synaptic potentiation
• monoatomic cation transmembrane transport
• negative regulation of protein catabolic process
• neuromuscular process controlling balance
• positive regulation of excitatory postsynaptic potential
• positive regulation of synaptic transmission, glutamatergic
• protein localization to postsynaptic membrane
• regulation of monoatomic cation transmembrane transport
• regulation of neuronal synaptic plasticity
• regulation of synaptic plasticity
• response to wounding
• synaptic transmission, glutamatergic

Molecular functions

• monoatomic cation channel activity
• NMDA glutamate receptor activity
• transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Cellular components

• endoplasmic reticulum membrane
• glutamatergic synapse
• NMDA selective glutamate receptor complex
• plasma membrane
• postsynaptic density membrane
• postsynaptic membrane

Protein domainsUniProt · Pfam · InterPro

• Ionotropic glutamate receptor, C-terminal
• Ionotropic glutamate receptor, metazoa
• Receptor, ligand binding region
• Ionotropic glutamate receptor
• Glutamate [NMDA] receptor, epsilon subunit, C-terminal
• Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
• Periplasmic binding protein-like I
• Ligand-gated ion channel
• Receptor family ligand binding region
• N-methyl D-aspartate receptor 2B3 C-terminus
• Ligated ion channel L-glutamate- and glycine-binding site

KeywordsUniProt

• Calcium
• Cell membrane
• Disulfide bond
• Glycoprotein
• Ion channel
• Ion transport
• Ligand-gated ion channel
• Magnesium
• Membrane
• Phosphoprotein
• Postsynaptic cell membrane
• Receptor
• Signal
• Synapse
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of GRIN2C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DLG4
• PATJ