GRID1

Protein identityUniProt · HPA

UniProt accession

Q9ULK0

Gene

GRID1

Ensembl

ENSG00000182771

Chromosome

10

Canonical length

1009 aa

Protein class

Predicted membrane proteins, Transporters

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

1009 residues, UniProt reviewed canonical sequence.

>Q9ULK0|GRID1
     1  MEALTLWLLP WICQCVSVRA DSIIHIGAIF EENAAKDDRV FQLAVSDLSL NDDILQSEKI
    61  TYSIKVIEAN NPFQAVQEAC DLMTQGILAL VTSTGCASAN ALQSLTDAMH IPHLFVQRNP
   121  GGSPRTACHL NPSPDGEAYT LASRPPVRLN DVMLRLVTEL RWQKFVMFYD SEYDIRGLQS
   181  FLDQASRLGL DVSLQKVDKN ISHVFTSLFT TMKTEELNRY RDTLRRAILL LSPQGAHSFI
   241  NEAVETNLAS KDSHWVFVNE EISDPEILDL VHSALGRMTV VRQIFPSAKD NQKCTRNNHR
   301  ISSLLCDPQE GYLQMLQISN LYLYDSVLML ANAFHRKLED RKWHSMASLN CIRKSTKPWN
   361  GGRSMLDTIK KGHITGLTGV MEFREDSSNP YVQFEILGTT YSETFGKDMR KLATWDSEKG
   421  LNGSLQERPM GSRLQGLTLK VVTVLEEPFV MVAENILGQP KRYKGFSIDV LDALAKALGF
   481  KYEIYQAPDG RYGHQLHNTS WNGMIGELIS KRADLAISAI TITPERESVV DFSKRYMDYS
   541  VGILIKKPEE KISIFSLFAP FDFAVWACIA AAIPVVGVLI FVLNRIQAVR AQSAAQPRPS
   601  ASATLHSAIW IVYGAFVQQG GESSVNSMAM RIVMGSWWLF TLIVCSSYTA NLAAFLTVSR
   661  MDNPIRTFQD LSKQVEMSYG TVRDSAVYEY FRAKGTNPLE QDSTFAELWR TISKNGGADN
   721  CVSSPSEGIR KAKKGNYAFL WDVAVVEYAA LTDDDCSVTV IGNSISSKGY GIALQHGSPY
   781  RDLFSQRILE LQDTGDLDVL KQKWWPHMGR CDLTSHASAQ ADGKSLKLHS FAGVFCILAI
   841  GLLLACLVAA LELWWNSNRC HQETPKEDKE VNLEQVHRRM NSLMDEDIAH KQISPASIEL
   901  SALEMGGLAP TQTLEPTREY QNTQLSVSTF LPEQSSHGTS RTLSSGPSSN LPLPLSSSAT
   961  MPSMQCKHRS PNGGLFRQSP VKTPIPMSFQ PVPGGVLPEA LDTSHGTSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRID1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

3

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

5.5 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GRID1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 160 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• GRID1-associated neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.24

gnomAD pLI

1

gnomAD missense Z

1.62

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• modulation of chemical synaptic transmission
• negative regulation of synaptic plasticity
• phospholipase C-activating G protein-coupled receptor signaling pathway
• regulation of postsynapse organization
• regulation of postsynaptic membrane neurotransmitter receptor levels
• social behavior
• synaptic signaling via neuropeptide
• synaptic transmission, glutamatergic

Molecular functions

• AMPA glutamate receptor activity
• G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
• identical protein binding
• transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
• GABA receptor activity

Cellular components

• AMPA glutamate receptor complex
• dendritic spine
• extracellular exosome
• GABA-ergic synapse
• glutamatergic synapse
• plasma membrane
• postsynaptic density membrane
• postsynaptic membrane
• trans-synaptic protein complex

Protein domainsUniProt · Pfam · InterPro

• Ionotropic glutamate receptor, C-terminal
• Ionotropic glutamate receptor, metazoa
• Receptor, ligand binding region
• Ionotropic glutamate receptor
• Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
• Periplasmic binding protein-like I
• Ligand-gated ion channel
• Receptor family ligand binding region
• Ligated ion channel L-glutamate- and glycine-binding site

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Glycoprotein
• Ion channel
• Ion transport
• Ligand-gated ion channel
• Membrane
• Postsynaptic cell membrane
• Receptor
• Signal
• Synapse
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of GRID1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CBLN1